慢性阻塞性肺疾病血清炎症标志物的研究进展

Research progress of serum inflammatory markers in chronic obstructive pulmonary disease

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种全身炎症性疾病,其发病率和死亡率正在逐年上升。COPD的主要特征是气道和肺实质的慢性炎症,伴随不完全可逆并呈进行性发展的气流受限。研究证实,细胞因子与多种炎性标志物在COPD的急性加重和恶化方面发挥着关键作用,如细胞因子白介素‐6(interleukin‐6,IL‐6)、IL‐8、IL‐10、肿瘤坏死因子‐α(tumor necrosis factor,TFN‐α)、干扰素‐γ(interferon‐γ,IFN‐γ)以及炎性标志物C-反应蛋白(C–reactive protein,CRP)、降钙素原(procalcitonin,PCT)、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)水平等。分析上述炎症标志物在COPD中的作用,有助于为其治疗及预防提供新思路。

Chronic obstructive pulmonary disease(COPD)is a systemic inflammatory disease that is currently the main cause of death worldwide.The main feature of COPD is chronic inflammation of the airways and lung parenchyma,accompanied by incomplete reversible and progressive airflow restriction.Numerous studies have confirmed that cytokines and various inflammatory markers play a crucial role in the acute and frequent exacerbation of chronic obstructive pulmonary disease,such as cytokines interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10),and tumor necrosis factor(TFN-α),interferon-γ(IFN-γ)and inflammatory markers such as C-reactive protein,procalcitonin,neutrophil to lymphocyte ratio(NLR),and platelet to lymphocyte ratio(PLR)levels.Deep understanding of the role of the aforementioned inflammatory markers in COPD can provide new ideas for its treatment and prevention.