食管癌细胞自噬途径与代谢异常关系的研究进展

Research progress on the relationship between autophagy pathway and metabolic abnormalities in esophageal cancer cells

食管癌是一种常见的恶性肿瘤,其发病率和死亡率较高。食管癌的背景和流行病学研究显示,不同地区和性别之间存在发病率差异,并且高温饮食、吸烟、饮酒和胃食管反流病等因素与食管癌发生密切相关。在分子机制方面,自噬途径和代谢异常在食管癌的发展中起着重要作用。自噬途径与食管癌细胞的生长、侵袭和耐药性等生物学特征密切相关。此外,食管癌细胞常表现出糖代谢异常、脂质代谢异常和氨基酸代谢异常等,这些代谢异常与癌细胞的增殖和侵袭能力密切相关。对自噬途径和代谢异常关系的研究有助于深入了解食管癌的生物学机制,并为研究新的治疗策略提供理论基础。

Esophageal cancer is a common malignant tumor with high incidence rate and mortality.Background and epidemiological studies of esophageal cancer show that there are differences in incidence rate between different regions and sexes,and factors such as high temperature diet,smoking,drinking and gastroesophageal reflux disease are closely related to the occurrence of esophageal cancer.In terms of molecular mechanisms,autophagy pathways and metabolic abnormalities are believed to play important roles in the development of esophageal cancer.The autophagy pathway is closely related to the biological characteristics of growth,invasion,and drug resistance of esophageal cancer cells.In addition,esophageal cancer cells often exhibit abnormalities in glucose metabolism,lipid metabolism,and amino acid metabolism,which are closely related to the proliferation and invasion ability of cancer cells.The study of the relationship between autophagy pathways and metabolic abnormalities contributes to a deeper understanding of the biological mechanisms of esophageal cancer and provides a theoretical basis for the development of new treatment strategies.