天麻钩藤饮联合倍他司汀治疗卒中后眩晕患者的效果

Effects of Tianma Gouteng decoction combined with Betahistine in treatment of patients with vertigo after stroke

目的:观察天麻钩藤饮联合倍他司汀治疗卒中后眩晕患者的效果。方法:选取2022年1月至2023年2月该院收治的88例卒中后眩晕患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各44例。对照组给予倍他司汀治疗,研究组在对照组基础上联合天麻钩藤饮治疗,比较两组临床疗效,眩晕症状消失时间和眩晕程度[眩晕障碍量表(DHI)]评分,治疗前后脑血流动力学指标[脑前动脉(ACA)血流速度、椎基底动脉(BA)血流速度]水平、血清学指标[降钙素基因相关肽(CGRP)、肌酸激酶同工酶(CK-MB)、脑钠肽(BNP)]水平及不良反应发生率。结果:研究组治疗总有效率为95.45%(42/44),高于对照组的79.55%(35/44),差异有统计学意义(P<0.05);研究组眩晕症状消失时间短于对照组,差异有统计学意义(P<0.05);治疗后,两组DHI评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组ACA、BA血流速度水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组CGRP、CK-MB、BNP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:天麻钩藤饮联合倍他司汀片治疗卒中后眩晕患者,可提高临床疗效,减轻眩晕症状,加快脑部动脉血液循环,改善神经信号传导,促进眩晕症状消失,效果优于单纯倍他司汀治疗。

Objective:To observe effects of Tianma Gouteng decoction combined with Betahistine in treatment of patients with vertigo after stroke.Methods:A prospective study was conducted on 88 patients with vertigo after stroke admitted to this hospital from January 2022 to February 2023.They were divided into control group and study group according to the random number table method,44 cases in each.The control group was treated with Betahistine,while the study group was treated with Tianma Gouteng decoction on the basis of that of the control group.The clinical efficacy,the disappearance time of vertigo symptoms and the vertigo degree[vertigo handicap inventory(DHI)]score,the cerebral hemodynamic indexes[anterior cerebral artery(ACA)bloodflow velocity,vertebrobasilar artery(BA)bloodflow velocity]levels,the serological indexes[calcitonin gene-related peptide(CGRP),creatine kinase isoenzyme(CK-MB),brain natriuretic peptide(BNP)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.45%(42/44),which was higher than 79.55%(35/44)in the control group,and the difference was statistically significant(P<0.05).The disappearance time of vertigo symptoms in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the DHI scores of the two groups were lower than those before the treatment,that in the study group was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of ACA and BA bloodflow velocity in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of CGRP,CK-MB and BNP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tianma Gouteng decoction combined with Betahistine tablets can improve the clinical efficacy,relieve the vertigo symptoms,accelerate the cerebral arterial blood circulation,improve the nerve signal transduction and promote the disappearance of vertigo symptoms in the patients with vertigo after stroke.Moreover,it is superior to single Betahistine treatment.