加味血府逐瘀汤联合孕三烯酮治疗子宫内膜异位症患者的效果

Effects of modified Xuefu Zhuyu decoction combined with Gestrinone in treatment of patients with endometriosis

目的:观察加味血府逐瘀汤联合孕三烯酮治疗子宫内膜异位症患者的效果。方法:选取2021年4月至2023年1月该院收治的84例子宫内膜异位症患者进行前瞻性研究,按随机数字表法将其分为对照组与研究组各42例。对照组采用孕三烯酮治疗,研究组在对照组基础上联合加味血府逐瘀汤治疗,比较两组临床疗效、治疗前后中医证候积分、炎性因子[肿瘤坏死因子-α(TNF-α)、单核细胞趋化因子-1(MCP-1)、白细胞介素-6(IL-6)]水平和不良反应发生率。结果:研究组治疗总有效率为95.24%(40/42),高于对照组的76.19%(32/42),差异有统计学意义(P<0.05);治疗后,两组腰骶疼痛、房事痛、经行腹痛、心烦不畅等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组TNF-α、MCP-1、IL-6水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加味血府逐瘀汤联合孕三烯酮治疗子宫内膜异位症患者可提高治疗总有效率,降低中医证候积分和炎性因子水平,其效果优于单纯孕三烯酮治疗。

Objective:To observe effects of modified Xuefu Zhuyu decoction combined with Gestrinone in treatment of patients with endometriosis.Methods:A prospective study was conducted on 84 patients with endometriosis admitted to this hospital from April 2021 to January 2023.They were divided into control group and study group according to the random number table method,42 cases in each.The control group was treated with Gestrinone,while the study group was treated with modified Xuefu Zhuyu decoction on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores before and after the treatment,the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.24%(40/42),which was higher than 76.19%(32/42)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as lumbosacral pain,atrial pain,abdominal pain and being upset in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of TNF-α,MCP-1 and IL-6 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Modified Xuefu Zhuyu decoction combined with Gestrinone in the treatment of the patients with endometriosis can improve the total effective rate of treatment and reduce the TCM syndrome scores and the levels of inflammatory factors.Moreover,it is superior to single Gestrinone treatment.