鼓室与耳后注射糖皮质激素治疗突发性耳聋患者的效果比较

Comparison of effects of tympanic and retroauricular injection of glucocorticoids in treatment of patients with sudden deafness

目的:比较鼓室与耳后注射糖皮质激素治疗突发性耳聋患者的效果。方法:回顾性分析2019年3月至2022年10月该院收治的94例突发性耳聋患者的临床资料,根据治疗方式不同将其分为对照组(n=47)和观察组(n=47)。对照组采用耳后注射糖皮质激素治疗,观察组采用鼓室注射糖皮质激素治疗,比较两组临床疗效、不同频率听力阈值、睡眠质量[匹兹堡睡眠指数量表(PSQI)]评分和不良反应发生率。结果:两组治疗总有效率比较,差异无统计学意义(P>0.05);治疗后,两组250 Hz、500 Hz、1000 Hz听力阈值均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组PSQI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率高于对照组,差异有统计学意义(P<0.05)。结论:鼓室与耳后注射糖皮质激素治疗突发性耳聋患者的治疗总有效率相当,但鼓室注射治疗的不同频率听力阈值和PSQI评分均低于耳后注射治疗,不良反应发生率高于耳后注射治疗。

Objective:To compare effects of tympanic and retroauricular injection of glucocorticoids in treatment of patients with sudden deafness.Methods:The clinical data of 94 patients with sudden deafness admitted to the hospital from March 2019 to October 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=47)and observation group(n=47).The control group was treated with postauricular injection of glucocorticoids,while the observation group was treated with tympanic injection of glucocorticoids.The clinical efficacy,the hearing threshold levels at different frequencies,the sleep quality[Pittsburgh sleep quality index(PSQI)]score,and the incidence of adverse reactions were compared between the two groups.Results:There was no significant difference in the total effective rate between the two groups(P>0.05).After the treatment,the hearing threshold levels at 250 Hz,500 Hz and 1000 Hz in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The PSQI scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusions:The total effective rates of tympanic injection and postauricular injection of glucocorticoid in the treatment of the patients with sudden deafness are similar;however,the hearing threshold levels and the PSQI scores at different frequencies of tympanic injection are lower than those of postauricular injection,and the incidence of adverse reactions is higher than that of postauricular injection.