肠道菌群-肠黏膜免疫在肠易激综合征发病机制中的研究进展

Progress in Study of Intestinal Flora-Intestinal Mucosal Immunity in Pathogenesis of Irritable Bowel Syndrome

肠易激综合征(IBS)具有发病率高、难治愈、易复发的特点。IBS的发病涉及多种机制,其中对IBS患者肠道菌群变化和肠黏膜免疫应答机制的研究一直以来受到广泛关注。肠道菌群的种类多、数量庞大且存在显著的个体差异,需要大量的样本和长时间的监测探明其在IBS发病中的影响。肠黏膜免疫是IBS患者临床症状表现的重要因素,同时肠黏膜免疫应答的启动与肠道菌群密切相关。因此,阐明肠道菌群-肠黏膜免疫在IBS发病中的机制有利于加深对IBS的认识,为临床治疗方案的选择提供方向和依据。

Irritable bowel syndrome(IBS)has a high incidence,is difficult to cure and is prone to recurrence.There are multiple mechanisms involved in the pathogenesis of IBS,among which the study of intestinal flora changes and intestinal mucosal immune response mechanisms in IBS patients has received widespread attention.The large variety,number and individual variation of gut flora requires large samples and prolonged monitoring to determine its influence in the development of IBS.Intestinal mucosal immunity is an important factor in the clinical symptoms of the patients with IBS,while the initiation of the intestinal mucosal immune response is closely linked to the intestinal flora.Therefore,elucidating the mechanism of intestinal flora-intestinal mucosal immunity in the pathogenesis of IBS is conducive to deepening the understanding of IBS and providing direction and basis for the choice of clinical treatment.