醒脑静联合高压氧治疗干预对急性一氧化碳中毒患者的影响研究

Study of the Effect of Wake-up Call Combined with Hyperbaric Oxygen Therapy Intervention on Patients with Acute Carbon Monoxide Poisoning

目的:探究急性一氧化碳中毒(ACOP)患者采取醒脑静联合高压氧治疗干预对其苏醒时间、迟发性脑病及肝肾功能的影响。方法:选取2021年1月—2022年1月信阳市中心医院收治的118例ACOP患者作为研究对象,根据抽签法分为两组,每组各59例。两组患者均接受常规基础治疗,在此基础上予以对照组高压氧治疗,予以观察组患者醒脑静联合高压氧治疗。评价两组患者临床疗效,记录苏醒时间、住院时间以及迟发性脑病发生情况。在治疗前和治疗后检测两组患者肝、肾功能。结果:观察组患者苏醒时间、住院时间相比对照组均显著更短,差异有统计学意义(t=15.774、9.484,P<0.05);迟发性脑病发生率相比对照组更低,差异有统计学意义(χ^(2)=11.863,P<0.05);治疗后,两组患者丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血尿素氮(BUN)、血肌酐(Scr)相比治疗前均有所下降,且观察组患者ALT、AST、BUN、Scr均显著低于对照组,差异有统计学意义(t=6.400、5.626、10.277、12.752,P<0.05);观察组患者临床总有效率相比对照组更高,差异有统计学意义(χ^(2)=12.861,P<0.05)。结论:ACOP患者采取醒脑静联合高压氧治疗干预具有确切的疗效,有助于缩短苏醒时间,降低迟发性脑病发生风险,促进肝、肾功能改善。

Objective:To investigate the effects of the combined hyperbaric oxygen therapy intervention with wake-up time,delayed encephalopathy,and hepatic and renal functions in patients with acute carbon monoxide poisoning(ACOP).Methods:118 cases of ACOP patients treated in the hospital from January 2021 to January 2022 were selected as the study subjects and were set into two groups according to the lottery method,with 59 cases in each group.Both groups of patients received conventional basic treatment,on the basis of which the control group was given hyperbaric oxygen therapy,and the patients in the observation group were given hyperbaric oxygen therapy combined with waking brain static.The clinical efficacy of the two groups of patients was evaluated,and the awakening time,hospitalization time,and the occurrence of delayed encephalopathy were recorded.The liver and kidney functions of the two groups were tested before and after treatment.Results:The time of awakening and hospitalization were significantly shorter in the observation group compared to the control group,and the difference was statistically significant(t=15.774,9.484,P<0.05).The incidence of delayed encephalopathy was lower in the study group than in the control group,and the difference was statistically significant(χ^(2)=11.863,P<0.05).After treatment,ALT,AST,BUN,and Scr decreased in both groups compared with those before treatment,and ALT,AST,BUN,and Scr in the observation group were significantly lower than those in the control group,with statistically significant differences(t=6.400,5.626,10.277,12.752,P<0.05).The total clinical effectiveness rate was higher in the observation group compared to the control group,and the difference was statistically significant(χ^(2)=12.861,P<0.05).Conclusion:ACOP patients taking wake-up call combined with hyperbaric oxygen therapy intervention has a definite efficacy,which helps to shorten the awakening time,reduce the risk of delayed encephalopathy,and promote the improvement of hepatic and renal functions.