TAT、PIC联合D-二聚体评估肿瘤患者凝血功能的价值探讨

Exploring the Value of Thrombus Markers Combined with D - dimerto Assess Coagulation Function in Cancer Patients

目的 检测肿瘤患者的TAT、PIC及D-二聚体的水平,探讨TAT、PIC联合D-二聚体检测在评估肿瘤患者凝血功能中的价值。方法 回顾性分析2022年1月至2023年5月在我院就诊的160例肿瘤患者作为病例组,同期体检健康人群30例作为对照组。通过统计学方法统计分析后比较两组TAT、PIC及D-二聚体水平的之间差异。Logistic回归分析肿瘤患者发生血液高凝状态的危险因素。通过ROC曲线分析上述指标在肿瘤患者凝血功能的诊断效能。结果 病例组的TAT、PIC以及D-二聚体检测水平明显比对照组高,P<0.05;Logistic回归显示,仅有TAT(OR=1.66,95%CI 1.23~2.25,P<0.05)为肿瘤患者血液发生高凝的危险因素;TAT、PIC、D-二聚体以及三者联合检测的曲线下面积分别为0.90、0.67、0.58与0.92,其评价肿瘤患者凝血为高凝状态的灵敏度分别为75%、56%、58%、与76%,特异性分别为90%、85%、65%与95%。结论TAT、PIC联合D-二聚体检测能更早地发现肿瘤患者凝血功能异常,能更好地提示肿瘤患者的血液高凝状态,从而及时地避免患者出现血栓的风险。

Objective To test different concentration levels of TAT,PIC and D-dimer in cancer patients,and to explore the value of TAT,PIC and D-dimer test in evaluating coagulation function in cancer patients.Methods A retrospective analysis was conducted including 160 cancer patients seen in our hospital from January,2022 to May,2023 as the case group,while 30 patients from the healthy population were examined as the control group.The concentrations of TAT,PIC and D-dimer were compared between groups.Logistic regression analysis was used to identify the risk factors for developing blood hypercoagulability status.The diagnostic efficacy of the above indexes in the coagulation function of tumor patients was analyzed by ROC curve.Results TAT,PIC and D-dimer had higher concentration levels in the case group than the control group(P<0.05);Logistic regression showed that:only TAT(OR=1.66,95%CI 1.23-2.25,P<0.05)was a risk factor for hypercoagulation in the blood of cancer patients;The area under the curve of TAT,PIC,D-dimer and the three combined tests were 0.90,0.67,0.58 and 0.92,respectively.The sensitivity to evaluate tumor patients as hypercoagulable state were 75%,56%,58%,and 76%,respectively,Specificity were 90%,85%,65%,and 95%,respectively.Conclusion TAT and PIC combined with D-dimer detection can detect the abnormal coagulation function of tumor patients earlier,and can better indicate the blood hypercoagulable state of cancer patients,so as to avoid the risk of thrombosis in time.