激素受体阳性乳腺癌术后骨转移患者临床特征及预后分析

Clinical characteristics and prognosis of postoperative bone metastasis in patients with Hormone receptor positive breast cancer

目的:通过激素受体阳性型乳腺癌术后骨转移患者的临床特征,分析影响患者预后的因素。方法:收集于某医院就诊的激素受体阳性型乳腺癌术后骨转移患者的临床资料,采用生存分析的方法研究影响乳腺癌骨转移术后患者预后的因素,影响预后的多因素分析采用Cox回归模型。结果:单因素分析显示,淋巴结受累、Ki-67表达水平≥30%、合并内脏转移、内分泌治疗等因素对骨转移患者的预后有影响。多因素分析显示,Ki-67表达水平≥30%、内分泌治疗是骨转移患者预后的独立影响因素。结论:乳腺癌骨转移患者Ki-67表达水平较高,且多伴有淋巴结受累及其他内脏转移,针对Luminal型骨转移患者,可以通过强化内分泌治疗有效延长其生存期。

Objective:To analyze the factors affecting the prognosis of patients with Hormone receptor positive breast cancer with bone metastasis after surgery.Methods:The clinical data of Hormone receptor positive breast cancer patients with bone metastases after surgery in one Hospital were collected.The survival analysis method was used to study the factors affecting the prognosis of breast cancer patients with bone metastases after surgery.Cox regression model was used to analyze the factors affecting the prognosis.Results:Univariate analysis showed that lymph node involvement,Ki-67 level≥30%,combined with visceral metastasis,endocrine therapy and other factors had an impact on the prognosis of patients with bone metastasis.Multivariate analysis showed that Ki-67 level≥30%and endocrine therapy were independent prognostic factors for patients with bone metastasis.Conclusion:Ki-67 level is higher in patients with bone metastasis of breast cancer,and most of them are accompanied by lymph node involvement and other visceral metastasis.For patients with Luminal bone metastasis,we can effectively extend their survival period through intensive endocrine therapy.