抗凝治疗预防窦性心律心力衰竭患者缺血性卒中研究进展

Anticoagulant Therapy for Ischemic Stroke Prevention in Sinus Rhythm Heart Failure

心力衰竭(心衰)是心血管疾病常见的终末期状态。全球心衰发病率的逐年递增造成了极大的医疗负担。研究发现,无论是合并心房颤动的心衰还是窦性心律的心衰,均会增加患者缺血性卒中的风险。临床上,心房颤动伴心衰的患者抗凝治疗的获益已被证实。但窦性心律的心衰患者缺血性卒中在抗凝治疗中的获益尚不明确,窦性心律心衰患者应用抗凝治疗的必要性仍有待探索。现就窦性心律心衰患者应用抗凝药物预防缺血性卒中的最新临床研究进展及现有的评估手段做一综述。

Heart failure always occurs after cardiovascular disease.The prevalence of heart failure is climbing globally,which induces massive burden to medical systems.Heart failure leads to increased risk of ischemic stroke in patients with or without atrial fibrillation.The clinical benefit of anticoagulant therapy in atrial fibrillation is definite.However,according to current evidence,the potential benefit and efficacy of anticoagulant therapy for preventing ischemic stroke in sinus rhythm heart failure is still uncertain.This review summarizes the progress about the evaluation of anticoagulant therapy in sinus rhythm heart failure from clinical research.