昼夜节律紊乱对急性心肌梗死的作用及机制的研究进展

Effect and Mechanism of Circadian Rhythm Disturbance on Acute Myocardial Infarction

昼夜节律是一种广泛存在于各种生物体内的节律性现象,当昼夜节律发生紊乱时会引起心血管疾病的发生。急性心肌梗死是一种常见的致死性心血管疾病,研究发现心肌梗死的发生存在昼夜节律改变。昼夜节律紊乱会对急性心肌梗死的发生发展产生严重影响,最终威胁人类生命健康。但昼夜节律紊乱促进急性心肌梗死发生发展的机制尚未明确,可能与自主神经系统、炎症、肾素-血管紧张素系统等机制有关。现对昼夜节律与急性心肌梗死之间的相关性以及潜在的机制展开综述。

The circadian rhythm is a rhythmic phenomenon widely existing in various organisms.When circadian rhythm is disrupted,it can cause the occurrence of cardiovascular disease.Acute myocardial infarction is a common fatal cardiovascular disease,and studies have found that there is a circadian rhythm change in the occurrence of myocardial infarction.The circadian rhythm disturbance will have a serious impact on the occurrence and development of acute myocardial infarction,ultimately threaten life and health.However,the mechanism by which circadian rhythm disturbance promote the occurrence and development of acute myocardial infarction is still unclear,and may be involved by mechanisms such as the autonomic nervous system,inflammation,renin-angiotensin system.This article reviews the correlation and potential mechanisms between circadian rhythm and acute myocardial infarction.