摘要
衰老是一种随着时间积累而发生的退行性变化的过程,年龄相关疾病与衰老密切相关。目前,探索衰老发生发展的原因和机制,寻找能有效延缓衰老、预防或治疗衰老疾病的药物,是人类面临的巨大挑战。衰老动物模型的构建是衰老研究必须涉及的重要手段。各种衰老动物模型都有不同的衰老机制,不同的衰老动物模型各有优缺点,适合不同的研究目的。本文以啮齿类动物所构建的衰老模型进行综述,为衰老研究提供资料。
Aging is a process of degenerative change that occurs as a result of time-related accumulation,associated with age-related diseases.Understanding the causes and mechanisms of aging and finding drugs that can effectively delay aging and prevent and cure age-related diseases currently present a great challenge for humans.Aging animal models thus represent an important tool in aging research,and various aging animal models have been created using different aging mechanisms.These different models having specific advantages and disadvantages,making them suitable for different research purposes.This review considers aging rodent models to provide information for aging research.
作者
李雪婵
韩乐
王雪文
柳立军
吴建军
王晶
LI Xuechan;HAN Le;WANG Xuewen;LIU Lijun;WU Jianjun;WANG Jing(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China;Reproductive Medicine Center,the First Hospital of Lanzhou University,Lanzhou 730000)
出处
《中国实验动物学报》
CSCD
北大核心
2023年第12期1605-1609,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(82060829,81760835)
甘肃省陇东生物资源保护利用与生态修复重点实验室开放基金(LDSWZY2002-3)。
关键词
衰老模型
啮齿类动物
机制
aging model
rodents
mechanism Conflicts of Interest:The authors declare no conflict of interest
