贞芪颗粒对仔猪断奶应激的影响

Effect of Zhenqi granules on weaning stress in piglets

本研究利用断奶仔猪模型探究复方中兽药贞芪颗粒对断奶仔猪生长、腹泻及断奶应激的影响。通过测定仔猪生长性能、腹泻率、空肠绒毛形态、生长及应激相关激素水平,发现21日龄断奶相比于28日龄断奶对仔猪的增重、腹泻率、肠道损伤的影响更大,表明21日龄断奶可对仔猪造成更严重的断奶应激。利用21日龄断奶仔猪模型,比较了贞芪颗粒给药组和不给药组仔猪的断奶应激相关指标,发现贞芪颗粒可显著降低仔猪腹泻率并缩短腹泻持续时间,27日龄时给药组仔猪皮质醇激素水平显著降低(P<0.05),43日龄时给药组仔猪血清中生长激素(GH)含量极显著升高(P<0.01)。以上结果表明,贞芪颗粒具有一定的缓解仔猪断奶腹泻、提高仔猪抗应激及促生长效果。

This study utilized a weaning piglet model to investigate the effects of a compound veterinary medicine,Zhenqi granules,on the growth,diarrhea incidence,and weaning stress of weaning piglets.Initially,the growth performance,occurrence of diarrhea,and morphology of the ileal villi in the piglets were observed,and levels of growth and stress hormones were measured.It was observed that the 21-day weaning had a greater effect on body weight,diarrhea rate,and intestinal damage compared to the 28-day weaning.This suggests that weaning at 21 days imposes a more significant weaning stress on piglets.Subsequently,we utilized a 21-day-old weaning piglet model to compare the administration of Zhenqi granules with the untreated group.It showed that Zhenqi granules could significantly reduce the rate of diarrhea and shortened the duration of the diarrhea.The level of growth hormone(GH)in serum of Zhenqi granules-treated group was significantly higher than those untreated(P<0.01)at 43 days old,while cortisol level was significantly lower at 27 days old(P<0.05).In this study,it is demonstrated that Zhenqi granules can alleviate diarrhea,improve anti-stress,and promote growth in piglet.