摘要
低碱性磷酸酶血症(hypophosphatasia, HPP)是一种罕见的以骨骼和(或)牙齿矿化障碍,伴有血清碱性磷酸酶活性降低为特征的遗传性内分泌系统疾病。asfotase alfa(AA)作为重组骨靶向人非特异性碱性磷酸酶获得美国FDA孤儿药认证,并于2015年上市用于HPP的治疗。本文就AA的作用机制、药动学特点、有效性、安全性及用法用量进行综述,为该药物用于HPP患者提供参考和证据支持。
Hypophosphatasia(HPP)is a rare hereditary endocrine system disease characterized by bone and/or tooth mineralization disorders accompanied by decreased serum alkaline phosphatase activity.Asfotase alfa(AA)received orphan drug approval by FDA as a recombinant bone-targeted human nonspecific alkaline phosphatase and was marketed in 2015 for the treatment of HPP.This paper reviews the mechanism of action,pharmacokinetic characteristics,efficacy,safety,usage and dosage of AA to provide reference and evidence support for the use of AA in the patients with HPP.
作者
刘清扬
后子靖
葛育
王少红
刘鑫
张波
唐彦
LIU Qing-yang;HOU Zi-jing;GE Yu;WANG Shao-hong;LIU Xin;ZHANG Bo;TANG Yan(Department of Pharmacy,Chinese Academy of Medical Sciences and Peking Union Medical College,Peking Union Medical Union Hospital,Beijing 100730,China;Department of Pharmacy,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2023年第24期2526-2530,共5页
Chinese Journal of New Drugs
基金
中央高水平医院临床科研业务费资助项目(2022-PUMCH-B-059)。