布南色林治疗精神分裂症的有效性及安全性的Meta分析

Meta-analysis of efficacy and safety of Blonanserin in the treatment of schizophrenia

目的根据发表的文献,系统地评估布南色林用于治疗成年精神分裂症的有效性及安全性。方法通过网络检索Medline、Pubmed、Embase、CNKI、Sinomed、万方等相关数据库关于布南色林治疗成人精神分裂症的双盲随机对照试验,检索时间为自数据库创建至2022年12月,对符合纳入标准的文章进行meta分析。结果共纳入相关文献6篇,根据合并结果显示布南色林和利培酮在改善PANSS总评分、阳性量表评分、阴性量表评分方面无差异。氟哌啶醇在改善PANSS总分方面优于布南色林。在引起高泌乳素血症(P<0.001)、血清泌乳素水平升高(P<0.001)、丙氨酸转氨酶升高(P=0.004)、天冬氨酸转氨酶升高(P=0.04)、体重增加方面(P=0.005),布南色林的危险度小于利培酮。在引起震颤(P=0.001)及静坐不能(P=0.01)方面,布南色林的危险度也小于氟哌啶醇。其余不良反应未见明显差异。结论布南色林在治疗成人精神分裂症方面有自己的优势,有效性及安全性良好。但是尚需要更多的研究加以验证和补充。

Objective To systematically evaluate the efficacy and safety of blonanserin for the treatment of schizophrenia in adults based on the current literature.Methods Double-blind controlled random trials of blonanserin for the treatment of schizophrenia in adults were searched through the internet in relevant databases,such as Medline,Pubmed,Embase,CNKI,Sinomed,and Wanfang in the range from the database founded to December 2022.Metaanalysis were performed on articles included.Results 6 included articles showed that there was no difference between blonanserin and risperidone in improving PANSS total scores,positive scale scores and negative scale scores.Haloperidol was superior to blonanserin in improving PANSS scores.Blonanserin was less likely not even than risperidone to cause hyperprolactinemia(P<0.001),elevating serum prolactin levels(P<0.001),elevating alanine aminotransferase levels(P=0.004),elevating aspartate aminotransferase levels(P=0.04),or increasing body weight(P=0.005),but also than haloperidol to cause tremors(P=0.001)and akathisia(P=0.01).No significant difference was found in other adverse reactions.Conclusion Blonanserin has its own advantages in efficacy and safety for the treatment of schizophrenia in adults.However,more studies are needed to confirm the former conclusion.