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齐拉西酮联合奥氮平对精神分裂症患者的效果及对血清BDNF水平的影响 被引量:1

The effect of ziprasidone combined with in schizophrenia patients and its influence on serum BDNF level
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摘要 目的分析齐拉西酮联合奥氮平治疗精神分裂症患者及对血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平的影响。方法本次研究对象来源于本院2020年1月~2023年1月住院的100例精神分裂症患者,根据抽签法分组(每组n=50),对比组接受奥氮平治疗,观察组接受齐拉西酮+奥氮平治疗,对比两组阳性和阴性症状量表(Positive and Negative Symptom Scale,PANSS)评分、临床疗效、血清神经生长因子(nerve growth factor,NGF)、脑源性神经营养因子和不良反应总发生率。结果观察组治疗后PANSS评分低于对比组,观察组临床总有效率(96.00%)高于对比组(72.00%),观察组治疗后血清NGF、BDNF水平均低于对比组(P<0.05)。不良反应总发生率观察组(10.00%)与对比组(6.00%)无明显差异(P>0.05)。结论齐拉西酮+奥氮平可有效减轻精神分裂症患者精神症状,改善神经营养,不增加不良反应。 Objective To analyze the effect of Ziprasidone+Olanzapine on serum brain derived neurotrophic factor(BDNF)in patients with schizophrenia.Methods The subjects of this study were 100 patients with schizophrenia hospitalized in our hospital from January 2020 to January 2023.They were divided into groups according to the drawing of lots(n=50 in each group).The control group received Olanzapine treatment,and the observation group received Ziprasidone+Olanzapine treatment.The positive and negative symptom scale(PANSS)scores,clinical efficacy,serum nerve growth factor(NGF)and brain derived nerve growth factor(BDNF),and overall incidence of adverse reactions were compared between two groups.Results After treatment,the PANSS score of the observation group was lower than that of the control group,and the total clinical effective rate(96.00%)of the observation group was higher than that of the control group(72.00%).The serum NGF and BDNF of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions was not difference between the observation group(10.00%)and the control group(6.00%)(P>0.05).Conclusion Ziprasidone combined with olanzapine can effectively alleviate the mental symptoms of patients with schizophrenia,improve their neuronutrition level.
作者 许晴丽 成加林 刘斌 牛军涛 XU Qingli;CHENG Jialin;LIU Bin(Shiyan Integrated Traditional Chinese and Western Medicine Hospital Psychiatric Department,Shiyan 442000,China)
出处 《国际精神病学杂志》 2023年第6期1296-1298,1302,共4页 Journal Of International Psychiatry
基金 十堰市引导性项目(编号:19Y111)。
关键词 齐拉西酮 奥氮平 精神分裂症 临床疗效 Ziprasidone Olanzapine Schizophrenia Clinical efficacy
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