美沙酮维持治疗联合心理行为干预对阿片类物质依赖者的效果及对抑郁、生活质量的影响

Effect of methadone maintenance therapy combined with psychobehavioral intervention on opioid dependence and its influence on their depression and quality of life

目的探讨美沙酮维持治疗联合心理行为干预对阿片类药物依赖者抑郁状况及生活质量的影响。方法纳入2020年1月~2022年12月期间我院门诊收治的96例阿片类药物依赖者作为研究对象,随机数字表法分成2组,各48例,对照组接受美沙酮维持治疗,研究组在对照组治疗基础上配合心理行为干预,干预前后采用药物成瘾者生活质量测定量表(Quality of life for drug addicts,QOL-DA)评价患者生活质量,采用贝克抑郁量表21项(Beck Depression Inventory-21,BDI-21)评价患者抑郁状况,对比两组患者生活质量评分及抑郁状况评分。结果干预后,研究组患者QOL-DA均高于对照组(P<0.05);干预后研究组患者BDI-21评分及汉密尔顿抑郁量表评分(Hamilton Depression Scale,HAMD)均显著低于对照组(P<0.05)。结论美沙酮维持治疗联合心理行为干预恢复阿片类药物依赖者躯体功能及社会功能,提高患者生活质量,改善患者抑郁情绪,值得临床推荐。

Objective To investigate the effects of methadone maintenance therapy combined with psychological and behavioral intervention on depression and quality of life in opioid dependent patients.Methods A total of 96patients with opioid dependence admitted to our hospital from January 2020 to December 2022 were included as research objects.They were divided into 2 groups with 48 cases in each group by random number table method.The control group received methadone maintenance treatment,and the research group was combined with psychological and behavioral intervention based on the treatment of the control group.Before and after the intervention,the quality of life of the patients was evaluated by the Drug Addiction Quality of Life Scale(Quality of life for drug addicts,QOL-DA),and the depression status of the patients was evaluated by the Baker Depression Scale(Beck Depression Inventory-21,BDI-21).The score of life quality and depression status of the two groups were compared.Results After intervention,QOL-DA in study group was higher than that in control group(P<0.05).After intervention,the scores of BDI-21 and Hamilton Depression Scale(Hamilton Depression Scale,HAMD)in the study group were significantly lower than those in the control group(P<0.05).Conclusion Methadone maintenance therapy combined with psychological and behavioral intervention can restore the physical and social functions,improve the quality of life and improve the depression of patients with opioid dependence,and is worthy of clinical recommendation.