重组人干扰素α-2b栓联合心理行为干预对慢性宫颈炎患者生活质量及心理状态的影响

Recombinant human interferonα-Effect of 2b suppository combined with psychological behavior intervention on quality of life,sleep disorder and psychological status of patients with chronic Cervicitis

目的探讨在慢性宫颈炎患者治疗中,选择重组人干扰素α-2b栓联合心理行为干预的价值,并分析该方案对患者生活质量、睡眠及心理状态的影响。方法选择2021年1月~2022年10月在我院门诊确诊为慢性宫颈炎的150例患者,以随机数字表法分成两组,一组接受重组人干扰素α-2b栓治疗(对照组),一组接受重组人干扰素α-2b栓+心理行为干预(观察组)。统计4周治疗后的临床疗效,并就治疗前后生活质量、睡眠状态、心理状态、炎症因子水平进行对比。结果较对照组而言,观察组75例患者经联合治疗后临床疗效更高(P<0.05);观察组统计的睡眠质量评分、焦虑及抑郁评分下降更显著(P<0.05);观察组统计的生活质量评分更高(P<0.05);观察组统计的炎症因子肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)、白介素6(interleukin-6,IL-6)水平降低更明显(P<0.05)。结论在慢性宫颈炎治疗中选择重组人干扰素α-2b栓联合心理行为干预措施可更有效改善患者心理状态,减轻疾病对患者睡眠质量的影响,提升患者生活质量。

Objective To explore the choice of recombinant human interferon in the treatment of chronic Cervicitis patientsα-The value of 2b suppository combined with psychological and behavioral intervention,and the impact of this plan on patients'quality of life,sleep,and psychological status.Methods 150 patients diagnosed as chronic Cervicitis in our outpatient department from January 2021 to October 2022 were selected and divided into two groups by random number table.One group received recombinant human interferonα-2b suppository treatment(control group),one group receiving recombinant human interferonα-2b suppository+psychological and behavioral intervention treatment(observation group).Calculate the clinical efficacy after 4 weeks of treatment and compare the quality of life,sleep status,psychological state,and levels of inflammatory factors before and after treatment.Results Compared with the control group,the clinical efficacy of 75 patients in the observation group increased after combined treatment(P<0.05).The sleep quality score,anxiety and depression score of the observation group decreased(P<0.05).The quality of life score of the observation group increased(P<0.05).Inflammatory factors and tumor necrosis factor counted by the observation groupαTumor Necrosis factor-α,TNF-α)、The level of interleukin-6(IL-6)decreased(P<0.05).Conclusion Recombinant human interferon should be selected in the treatment of chronic Cervicitisα-The combination of 2b suppositories and psychological behavioral intervention measures can improve patients'psychological state,reduce the impact of diseases on their sleep quality,and improve their quality of life.