PLR、NLR、CRP表达水平与缺血性脑卒中后抑郁的关系

Relationship between the expression levels of PLR,NLR,CRP and depression after ischemic stroke

目的探讨血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)、C反应蛋白(CRP)表达水平与缺血性脑卒中后抑郁(PSD)的关系。方法选取我院2020年7月~2022年7月期间收治的134例缺血性脑卒中患者,并随访3个月,根据PSD情况分为PSD组与非PSD组,对比其基线资料;并根据汉密尔顿抑郁量表(HAMD)分为轻度抑郁组和中重度抑郁组,并分析PLR、NLR、CRP与缺血性脑卒中后抑郁严重程度的关系。结果PSD组PLR、NLR、CRP水平均高于非PSD组,中重度抑郁组PLR、NLR、CRP水平高于轻度抑郁组(P<0.05)。二元logistic回归分析显示PLR、NLR、CRP是PSD发生的独立危险因素(P<0.05)。结论PLR、NLR、CRP或许可作为预测缺血性脑卒中后抑郁患病及严重程度的血液性参考指标。

Objective To investigate the relationship between platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR),C-reactive protein(CRP)expression level and post-ischemic stroke depression(PSD).Methods A total of 134 patients with ischemic stroke admitted to our hospital from July 2020 to July 2022 were selected and followed up for 3 months.They were divided into PSD group and non-PSD group according to their PSD status.Their baseline data were compared.According to Hamilton Depression Scale(HAMD),they were divided into mild depression group and moderate to severe depression group,and the relationship between PLR,NLR,CRP and the severity of depression after ischemic stroke was analyzed.Results The levels of PLR,NLR and CRP in PSD group were higher than those in non-PSD group,and the levels of PLR,NLR and CRP in moderate to severe depression group were higher than those in mild depression group,with statistical significance(P<0.05).PLR,NLR and CRP are independent risk factors for the occurrence of PSD(P<0.05).Conclusion PLR,NLR and CRP maybe can be used as blood reference indicators to predict the incidence and severity of depression after ischemic stroke.