丁苯酞序贯治疗烟雾病合并脑梗死患者的效果

Effect of Butylphthalide Sequential Therapy on Patients with Moyamoya Disease Complicated with Cerebral Infarction

目的:探讨丁苯酞序贯治疗烟雾病合并脑梗死患者的效果。方法:选取2020年7月—2023年1月我院收治的102例烟雾病合并脑梗死患者作为研究对象,按照随机数字表法分为对照组及观察组,各51例。对照组给予单纯抗栓治疗,观察组在对照组基础上增加丁苯酞序贯治疗,比较两组脑灌注量、侧支循环改善情况、认知功能、独立生活能力及不良反应。结果:治疗3个月,观察组rCBV及rCBF低于对照组,MTT及TTP高于对照组(P<0.05);观察组侧支循环改善率高于对照组(P<0.05);观察组MoCA评分、MBI评分高于对照组(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:丁苯酞序贯治疗烟雾病合并脑梗死患者可有效改善患者脑灌注量及侧支循环情况,改善患者认知功能,提高患者的独立生活能力且安全性高。

Objective:To investigate the effect of butylphthalide sequential therapy in patients with moyamoya disease complicated with cerebral infarction.Methods:A total of 102 patients with moyamoya disease complicated with cerebral infarction admitted to our hospital from July 2020 to January 2023 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 51 patients in each group.The control group was treated with simple antithrombotic therapy,and the observation group was treated with butylphthalide sequential therapy on the basis of the control group.The cerebral perfusion,improvement of collateral circulation,cognitive function,independent living ability and adverse reactions were compared between the two groups.Results:After 3 months of treatment,rCBV and rCBF in the observation group were lower than those in the control group,and MTT and TTP were higher than those in the control group(P<0.05).The improvement rate of collateral circulation in the observation group was higher than that in the control group(P<0.05).The MoCA score and MBI score of the observation group were higher than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:Sequential treatment of butylphthalide in patients with moyamoya disease complicated with cerebral infarction can effectively improve the cerebral perfusion and collateral circulation,improve the cognitive function of patients,and improve the independent living ability of patients with high safety.