阿司匹林分别联合氯吡格雷、阿加曲班对短暂性脑缺血发作病人缺血修饰白蛋白、神经功能影响

Effects of aspirin combined with clopidogrel and aspirin combined with agatroban on ischemic modified albumin and neural function in patients with transient ischemic attack

目的:探索阿司匹林联合氯吡格雷、阿司匹林联合阿加曲班对短暂性脑缺血发作病人缺血修饰白蛋白(IMA)、神经功能影响。方法:124例短暂性脑缺血发作病人根据随机数字表法分为2组,对照组62例采用阿司匹林联合氯吡格雷治疗,观察组62例采用阿司匹林联合阿加曲班治疗,均治疗14 d后,比较2组各时间段的IMA、美国国立卫生(NIHSS)量表评分、纤维蛋白原(FIB)、活化部分凝血酶时间(APTT)、凝血酶原时间(PT)、基质金属蛋白酶9(MMP-9)及疾病缓解率。结果:2组MMP-9、FIB、PT、APTT以及各时间段NIHSS评分比较差异均无统计学意义(P>0.05),观察组治疗后14 d的IMA高于对照组(P<0.05),同时观察组治疗后7、10、14 d的疾病缓解率均高于对照组(P<0.05)。结论:阿司匹林分别联合氯吡格雷、阿加曲班均可减轻神经功能受损,改善IMA、凝血功能,但对于短暂性脑缺血发作病人而言,运用阿司匹林联合阿加曲班治疗效果更佳。

Objective To explore the effects of aspirin combined with clopidogrel,aspirin combined with agatroban on ischemic modified albumin(IMA)and neural function in patients with transient ischemic attack.Methods A total of 124 patients with transient ischemic attack were divided into two groups according to the random number table method.The control group(62 cases)was treated with aspirin and clopidogrel,and the observation group(62 cases)was treated with aspirin and agatroban.After 14 days of treatment,the scores of IMA,National Institute of Health stroke scale(NIHSS)score,fibrinogen(FIB),activated partial thrombin time(APTT),prothrombin time(PT),matrix metalloproteinase 9(MMP-9)and disease remission rate were compared between the two groups.Results There was no statistical difference in MMP-9,FIB,PT,APTT and NIHSS scores in each time period between the two groups(P>0.05).The IMA in the observation group was higher than that in the control group 14 days after treatment(P<0.05).At the same time,the disease remission rates in the observation group were higher than those in the control group 7 days,10 days and 14 days after treatment(P<0.05).Conclusions Aspirin combined with clopidogrel and aspirin combined with agatroban can reduce neural impairment,improve IMA and blood coagulation function,but for patients with transient ischemic attack,aspirin combined with agatroban is more effective.