益气复元合剂治疗非痴呆型血管性认知障碍的临床研究

A Clinical Study on the Treatment of Non Dementia Vascular Cognitive Impairment with Yiqi Fuyuan Mixture

[目的]探讨益气复元合剂对非痴呆型血管性认知障碍(Non dementia vascular cognition impairment,VCIND)患者认知及执行能力及P300的影响,并且与丁苯酞软胶囊相对比,比较两组疗效的差异。[方法]采用简单随机数字表法将60例VCIND患者随机分治疗组和对照组各30例。所有患者均予以抗血小板聚集、调控血压、血糖、降脂、稳斑等基础治疗;在上述治疗基础上,治疗组加用益气复元合剂50ml口服,tid;对照组加用丁苯酞软胶囊口服0.2gtid,疗程为3个月;评估两组患者治疗前后MoCA和MMSE评分,检测P300潜伏期及波幅的改变,同时检测所有患者治疗前后肝肾功能、血常规、凝血功能等指标,记录不良反应。[结果]治疗前两组患者的MMSE、MoCA、P300波幅及潜伏期无明显差异(P>0.05)。治疗后两组患者MMSE、MoCA评分均升高,与治疗前相比有统计学意义(P<0.05),组间相比无明显差异(P>0.05);治疗后两组患者的P300潜伏期缩短、波幅增高,与治疗前相比有明显差异(P<0.05),且治疗组优于对照组(P<0.05)。[结论]益气复元合剂治疗能够改善VCIND患者的认知力和执行力,与丁苯酞具有相似的疗效,但在改善P300潜伏期及波幅方具有潜在的优势(P<0.05)。

[Objective]To investigate the effect of Yiqi Fuyuan mixture on cognitive and executive abili-ty,as well as P300 in patients with Non dementia vascular cognition impairment(VCIND),to compare the difference of curative effect between the two groups.[Methods]A total of 60 patients with VCIND were e-qually and randomly divided into treatment group(n=30)and control group(n=30).All the patients were treated with basic therapy such as anti-platelet aggregation,regulating blood pressure,blood sugar,reducing lipid and stabilizing plaque,on the basis of above treatment,the treatment group was added with Yiqi Fuyuan mixture 50ml tid orally;The patients in the control group were treated with 0.2 g tid of butylphthalide soft capsule orally for 3 months,and the changes of MOCA and MMSE scores,P300 latency and amplitude were detected before and after treatment,at the same time,liver and kidney function,blood routine and coagulation function were detected before and after treatment,and adverse reactions were recorded.[Results]there was no significant difference in the amplitude and latency of MMSE,MOCA,P300 between the two groups before treatment(P>0.05).After treatment,the scores of MMSE and MOCA in both groups were significantly higher than those before treatment(P<0.05);there was no significant difference in the improvement of MMSE and MOCA scores between the two groups(P>0.05),however the P300 latenct shortened and amplitude in-creased had significant difference before and after treatment(p<0.05),and the treatment group was superior to the control group(p<0.05).[Conclusion]Yiqi Fuyuan mixture can improve the cognitive ability and ex-ecutive ability of VCIND patients,which is similar to that of butylphthalide,but has potential advantages in improving P300 latency and amplitude(p<0.05).