中药复方治疗糖尿病合并失眠随机对照试验的Meta分析

Meta-analysis of Randomized Controlled Trials of Chinese Herbal Compound in the Treatment of Diabetes Mellitus Complicated with Insomnia

目的系统评价中药复方治疗糖尿病合并失眠随机对照试验的临床有效性和安全性。方法检索医学数据库CNKI、VIP、万方、PubMed、EMBase、The Cochrane Library,收集并评价截至2023年2月的符合纳入标准的随机对照试验研究,并根据治疗有效率、匹兹堡睡眠指数(PSQI)量表评分、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2hPBG)等结局指标提取并分析相关数据,Meta分析采用Review Manager 5.4软件进行。结果共13篇文献符合标准,总计纳入病例1183例,其中实验组599例,对照组584例。Meta分析结果表明中药复方组在干预后的治疗有效率、PSQI量表评分以及FPG、HbA1c、2hPBG水平均优于西药对照组。结论Meta分析结果提示中药复方改善糖尿病合并失眠的作用优于西药。

Objective To systematically evaluate the clinical efficacy and safety of Chinese herbal compound in the treatment of diabetes with insomnia in a randomized controlled trial.Methods The medical databases CNKI,VIP,Wanfang,PubMed,EMBase,and The Cochrane Library were searched to collect and evaluate randomized controlled trial studies that met the inclusion criteria as of February 2023,and relevant data were extracted and analyzed according to outcome measures such as treatment response rate,Pittsburgh sleep quality index(PSQI)scale score,fasting plasma glucose(FPG),hemoglobin A1c(HbA1c),and 2 h postprandial blood glucose(2hPBG).Meta-analysis was performed using Review Manager 5.4 software.Results Thirteen articles met the criteria,and a total of 1183 cases were included,including 599 cases in the experimental group and 584 cases in the control group.Meta-analysis showed that the treatment response rate,PSQI scale score,FPG,HbA1c and 2hPBG levels in the Chinese herbal compound group were better than those in the Western medicine control group after intervening diabetic patients with insomnia.Conclusion Meta-analysis results suggest that Chinese herbal compound is superior to western medicine in improving diabetes with insomnia.