药物注射法建立膝骨性关节炎动物模型研究进展

The Research Progress of Drug Injection Method for Establishing Animal Models of Knee Osteoarthritis

在膝骨性关节炎(KOA)的发病和治疗机制的研究中,建立可靠的实验模型动物是一个重要的环节。当前复制KOA模型动物的方法多样,因研究方法和观察指标不同,往往采取不同的建模方式,如药物注射,局部手术等。不同造模方法的建模周期和模型动物的病理变化多有差异。因此,快速有效建立稳定KOA模型动物方法值得深入探讨。本文结合近十年关于KOA的动物实验研究文献,就药物注射法建立KOA动物模型的特点和优势展开分析,并对相关研究进展进行梳理,以期为KOA的动物实验研究提供参考。

In the study of the pathogenesis and therapeutic mechanisms of knee osteoarthritis(KOA),the establishment of reliable experimental model animals is an important aspect.Current methods for replicating KOA model animals are diverse,and different modeling approaches,such as drug injection and local surgery,are often adopted depending on the study methods and observation indexes.The modeling period and the pathological changes of model animals mostly vary among dfferent modeling methods,so the rapid and effective method of establishing stable KOA model animals deserves in-depth exploration.In this paper,we analyzed the characteristics and advantages of the drug injection method for establishing KOA animal models and reviewed the related research progress,in order to provide some reference for the animal experimental research of KOA,taking into account the animal experimental research literature on KOA in the past ten years.