心脏康复运动疗法结合沙库巴曲缬沙坦钠治疗慢性心衰的效果分析

Analysis of the therapeutic effect of cardiac rehabilitation therapy combined with sacubitril/valsartan in the treatment of chronic heart failure

目的:探讨心脏康复运动疗法结合沙库巴曲缬沙坦钠治疗慢性心衰(CHF)的效果。方法:选取120例CHF患者为研究对象,按照治疗方式不同将患者分为对照组与观察组,每组各60例。对照组接受沙库巴曲缬沙坦钠治疗;观察组在此基础上接受心脏康复运动治疗。治疗3个月后,比较两组患者心肺功能指标、无创血流动力学参数及运动耐力水平。结果:治疗后,两组患者左心室射血分数(LVEF)、左心室收缩期末容量(LVESV)及左心室舒张期末容量(LVEDV)均升高,且观察组高于对照组(P<0.05);两组患者左心室收缩期末内径(LVESD)、左心室舒张期末内径(LVEDD)均低于治疗前(P<0.05),但组间差异无统计学意义(P>0.05)。治疗后,观察组患者用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC及最大通气量(MVV)均高于治疗前及对照组;两组患者心排血量、心排血指数、每搏输出量、每搏指数、6 min步行距离(6MWD)、运动峰耗氧量(PVO_(2))及氧脉搏(VO_(2)/HR)均高于治疗前,且观察组高于对照组(P<0.05)。结论:心脏康复运动治疗结合沙库巴曲缬沙坦钠治疗有利于改善CHF患者心肺功能及血流动力参数,提升运动耐力。

Objective:To investigate the efficacy of cardiac rehabilitation exercise therapy combined with sacubitril/valsartan in the treatment of chronic heart failure(CHF).Methods:120 patients with CHF were selected as the study subjects and divided into control group and observation group according to different treatment method,with 60 cases in each group.The control group received the treatment of sacubactril valsartan sodium,and the observation group received the cardiac rehabilitation exercise on this basis.After 3 months of treatment,the cardiopulmonary function indicators,non-invasive hemodynamic parameters,and exercise endurance were compared between the two groups.Results:After treatment,the left ventricular ejection fraction(LVEF),left ventricular end systolic volume(LVESV),and left ventricular end diastolic volume(LVEDV)in both groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05).The left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)were lower than those before treatment(P<0.05),there were no statistically significant difference between the groups(P>0.05).After treatment,the forced vital capacity(FVC),first second forced expiratory volume(FEV1),FEV1/FVC,and maximum ventilation volume(MVV)of the observation group were higher than those before treatment and in the control group(P<0.05).Cardiac output and its index,stroke output and its index,6-minute walking distance,peak exercise oxygen consumption(PVO_(2)),and oxygen pulse rate(VO_(2)/HR)in both groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05).Conclusion:The combination of cardiac rehabilitation exercise therapy and sacubitril/valsartan therapy is beneficial for improving cardiopulmonary function and hemodynamic parameters in CHF patients,and enhancing the exercise endurance.