肾胺酶与心房颤动的相关性研究

Correlation between renalase and atrial fibrillation

目的:探讨肾胺酶在心房颤动(房颤)的发生及发展中的作用。方法:按照房颤与否将208例患者分为房颤组和对照组,每组各104例;按照房颤类型将房颤组分为持续性房颤组(n=68)与阵发性房颤组(n=36)。收集各组受试者的一般资料及静脉血,测定血浆肾胺酶、总儿茶酚胺浓度,比较两组肾胺酶及儿茶酚胺浓度的差异,分析其与房颤之间的相关性。结果:房颤组肾胺酶浓度低于对照组(P<0.05);阵发性房颤组与持续性房颤组肾胺酶浓度的差异无统计学意义(P>0.05)。房颤组与对照组之间及阵发性房颤组和持续性房颤组之间总儿茶酚胺浓度无统计学差异(P>0.05)。房颤组左房内径组大于对照组(P<0.05),持续性房颤组左房内径大于阵发性房颤组(P<0.05)。相关性分析显示,肾胺酶浓度与儿茶酚胺浓度负相关(r=-0.167,P<0.05)、与左房内径负相关(r=-0.212,P<0.05),但肾胺酶浓度与收缩压、舒张压、心率之间无相关性(P>0.05);总儿茶酚胺浓度与心率(r=0.176,P<0.05)、左房内径正相关(r=0.188,P<0.05),但总儿茶酚胺与收缩压、舒张压之间无相关性(P>0.05)。二元Logistic回归分析显示,肾胺酶是房颤发生的保护因素(OR<1,P<0.05)。结论:肾胺酶可能参与房颤的发生,并改善心脏重构。

Objective:To investigate the role of renalase in the occurrence and development of atrial fibrillation(AF).Methods:104 AF patients were selected as AF group and 104 non-AF patients as control group.According to the type of atrial fibrillation,the atrial fibrillation group was divided into persistent atrial fibrillation group(n=68)and paroxysmal atrial fibrillation group(n=36).The patient-related information were collected,and the plasma concentrations of renalase and total catecholamine were determined by venous blood of the subjects.The concentrations of renal aminase and total catecholamine were compared between the two groups,and the correlation between that and atrial fibrillation was analyzed.Results:The concentration of renalase in atrial fibrillation group was lower than that in control group(P<0.05).The difference in renalase concentration between the paroxysmal atrial fibrillation group and the persistent atrial fibrillation group was not statistically significant(P>0.05).There was no significant difference in total catecholamine concentration between atrial fibrillation group and control group or between paroxysmal atrial fibrillation group and persistent atrial fibrillation group(P>0.05).The left atrial diameter of atrial fibrillation group was higher than that of control group(P<0.05),and the left atrial diameter of persistent atrial fibrillation group was higher than that of paroxysmal atrial fibrillation group(P<0.05).Correlation analysis showed that renalase concentration was negatively correlated with catecholamine concentration(P<0.05,r=-0.167)and left atrial diameter(P<0.05,r=-0.212),but there was no significant correlation between renalase concentration and systolic blood pressure,diastolic blood pressure and heart rate(P>0.05).Total catecholamine concentration was positively correlated with heart rate(P<0.05,r=0.176)and left atrial diameter(P<0.05,r=0.188),but there was no significant correlation between total catecholamine concentration and systolic and diastolic blood pressure(P>0.05).The Logistic regression analysis showed that renalase was a protective factor for atrial fibrillation(P<0.05,OR<1).Conclusion:Renalase may be involved in the occurrence of atrial fibrillation and help improve cardiac remodeling.