黄芪当归补血汤治疗老年骨折患者术后非感染性发热

Huangqi Danggui Buxue Decoction in Treating Postoperative Non-infectious Fever in Elderly Fracture Patients

目的:分析黄芪当归补血汤预防老年骨折患者术后非感染性发热的综合疗效。方法:110例老年骨折术后患者随机平均分为对照组、观察组,对照组给予常规治疗,观察组在对照组治疗基础上给予黄芪当归补血汤。比较两组患者临床疗效、中医证候积分、红细胞相关指标、炎症因子水平、安全性。结果:观察组有效率为92.73%(51/55),高于对照组的76.36%(42/55),两组有效率比较,差异有统计学意义(P<0.05)。治疗后,观察组中医证候积分中肌热面红、头昏眼花、烦渴欲饮、面白少华等评分分别为(0.59±0.18)分、(0.62±0.20)分、(0.69±0.23)分、(0.73±0.25)分,均低于同期对照组的(0.81±0.24)分、(0.89±0.27)分、(0.94±0.28)分、(0.98±0.29)分(P<0.05)。治疗后,观察组红细胞计数、血红蛋白、红细胞比容水平分别为(3.99±0.68)×10^(12) L^(-1)、(134.85±14.80)g·L^(-1)、(42.61±7.23)%,分别高于同期对照组的(3.50±0.63)×10^(12) L^(-1)、(121.62±13.27)g·L^(-1)、(37.01±6.32)%(P<0.05)。治疗后,观察组炎症因子Toll样受体4、核因子-κB、前列腺素E2分别为(43.76±6.28)μg·L^(-1)、(74.25±8.24)μg·L^(-1)、(17.21±4.20)μg·L^(-1),分别低于同期对照组的(49.83±7.12)μg·L^(-1)、(81.04±9.57)μg·L^(-1)、(20.65±4.78)μg·L^(-1)(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄芪当归补血汤治疗老年骨折患者术后非感染性发热疗效显著,可改善患者中医证候、血常规指标,降低炎症因子水平,且治疗安全性良好。

Objective:To analyze the comprehensive efficacy of Huangqi Danggui Buxue Decoction in preventing postoperative non infectious fever in elderly fracture patients.Method:110 elderly patients with non infectious fever after fracture surgery were randomly divided into a control group and an observation group.The control group received routine treatment,while the observation group received Huangqi Danggui Buxue Decoction on basis of the control group′s treatment.Compare the clinical efficacy,traditional Chinese medicine syndrome score,red blood cell related indicators,inflammatory factor levels,safety and other indicators between two groups of patients.Result:The effective rate of the observation group was 92.73%(51/55),which was higher than the control group′s 76.36%(42/55).The difference in effective rates between the two groups was statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of the observation group,including muscle heat,redness,dizziness and dizziness,restlessness and thirst,and white complexion,were(0.59±0.18)points,(0.62±0.20)points,(0.69±0.23)points,and(0.73±0.25)points,respectively,lower than the control group′s(0.81±0.24)points,(0.89±0.27)points,(0.94±0.28)points,and(0.98±0.29)points during the same period(P<0.05).After treatment,the observation group′s red blood cell count,hemoglobin,and hematocrit levels were(3.99±0.68)10^(12) L^(-1),(134.85±14.80)g·L^(-1),and(42.61±7.23)%,respectively,higher than the control group′s(3.50±0.63)1012 L^(-1),(121.62±13.27)g·L^(-1),and(37.01±6.32)%(P<0.05)during the same period.After treatment,observe the levels of inflammatory factor Toll like receptor 4 and nuclear factor in the observation group-κB.The levels of prostaglandin E2 were(43.76±6.28)μg·L^(-1),(74.25±8.24)μg·L^(-1),and(17.21±4.20)μg·L^(-1),respectively,lower than the control group′s(49.83±7.12)μg·L^(-1),(81.04±9.57)μg·L^(-1),and(20.65±4.78)μg·L^(-1)during the same period(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Huangqi Danggui Buxue Decoction has a significant therapeutic effect on postoperative non infectious fever in elderly fracture patients.It can improve traditional Chinese medicine syndrome and blood routine indicators,reduce levels of inflammatory factors,and has good treatment safety.