富血小板血浆基于Wnt/β-catenin信号通路治疗膝骨关节炎的研究现状

Current status of research on treatment of knee osteoarthritis with platelet-rich plasma based on Wnt/β-catenin signaling pathway

膝骨关节炎(KOA)是以关节软骨磨损为主要特点的慢性退行性骨病,早期主要表现为膝关节疼痛、肿胀、关节活动受限,最终可导致患者膝关节交锁、畸形和残疾。Wnt/β-catenin信号通路在KOA发生、发展过程中具有重要作用,可通过调控细胞增殖、分化进而影响关节软骨和软骨下骨的代谢平衡。富血小板血浆(PRP)作为KOA的新兴疗法,可通过延缓软骨退化、促进软骨再生、抑制关节内炎症等方式来减缓KOA的病理进展,这可能与其参与调控Wnt/β-catenin信号通路有关。本文主要介绍Wnt/β-catenin信号通路与KOA之间的病理联系、PRP在KOA治疗中的应用及PRP基于Wnt/β-catenin通路治疗KOA的研究现状,旨在为PRP临床治疗KOA提供更多的理论依据。

Knee osteoarthritis(KOA)is a chronic degenerative bone disease characterized by the wear of articular cartilage.In the early stage,the main manifestations are knee pain,swelling,and limited joint movement,which can eventually lead to locking of the knee,deformity,and disability.Wnt/β-catenin signaling pathway plays an important role in the pathogenesis and development of KOA,which influences the metabolic balance of articular cartilage and subchondral bone by regulating cell proliferation and differentiation.Platelet-rich plasma(PRP),as a new treatment for KOA,can slow down the pathologic progression of KOA by delaying cartilage degeneration,promoting cartilage regeneration,and inhibiting intra-articular inflammation,which may be related to its involvement in the regulation of Wnt/β-catenin signaling pathway.This article mainly introduces the pathological relationship between Wnt/β-catenin signaling pathway and KOA,the application of PRP in the treatment of KOA,and the research status of PRP based on Wnt/β-catenin pathway in the treatment of KOA,aiming to provide more theoretical basis for the clinical treatment of KOA with PRP.