畲药食凉茶组方联合经鼻持续气道正压通气治疗痰湿壅盛型阻塞性睡眠呼吸暂停低通气综合征伴肥胖的临床效果

Clinical effect of She medicine Shiliangcha Prescription combined with continuous positive airway pressure per nasal in the treatment of obstructive sleep apnea hypopnea syndrome and obesity with pattern of phlegm-damp congestion and excessiveness

目的 观察畲药食凉茶组方联合经鼻持续气道正压通气(CPAP)治疗痰湿壅盛型阻塞性睡眠呼吸暂停低通气综合征(OSAHS)伴肥胖患者的效果。方法 选取2021年1月至2023年1月浙江省丽水市中医院收治的痰湿壅盛型OSAHS伴肥胖患者100例,按随机数字表法将其分为观察组和对照组,各50例。对照组进行经鼻CPAP治疗,观察组进行经鼻CPAP联合畲药食凉茶组方治疗,两组均连续治疗12周。比较两组临床疗效及治疗前后中医证候积分、多导睡眠图参数[呼吸暂停低通气指数(AHI)、平均动脉血氧饱和度(MSaO_(2))、SaO_(2)<90%时间/全部睡眠时间比值]、血清指标[C反应蛋白(CRP)、白细胞介素-8(IL-8)]和体重指数(BMI)。结果 两组疗效比较,差异无统计学意义(P>0.05)。治疗后,两组中医证候积分、AHI、SaO_(2)<90%时间/全部睡眠时间比值、体重指数及血清CRP、IL-8均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组MSaO_(2)均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论 畲药食凉茶组方联合经鼻CPAP治疗痰湿壅盛型OSAHS合并肥胖患者,可有效改善其体征和临床症状。

Objective To observe the efficacy of She medicine Shiliangcha Prescription combined with continuous positive airway pressure(CPAP)per nasal in the treatment of obstructive sleep apnea hypopnea syndrome(OSAHS)and obesity patients with pattern of phlegm-damp congestion and excessiveness.Methods A total of 100 OSAHS and obesity patients with pattern of phlegm-damp congestion and excessiveness admitted to Lishui Traditional Chinese Medicine Hospital of Zhejiang Province from January 2021 to January 2023 were selected,and they were divided into observation group and control group according to the random number table method,with 50 cases in each group.The control group was treated with CPAP per nasal,and the observation group was treated with CPAP per nasal combined with She medicine Shiliangcha Prescription,both groups were treated for 12 weeks.The clinical efficacy,and traditional Chinese medicine syndrome scores,poly-somnography parameters(apnea hypopnea index[AHI],mean arterial oxygen saturation[MSaO_(2)],ratio of SaO_(2)<90%time/total sleep time),serum indexes(C-reactive protein[CRP],interleukin-8[IL-8]),and body mass index(BMI)before and after treatment were compared between the two groups.Results There was no significant difference in the efficacy between the two groups(P>0.05).After treatment,the traditional Chinese medicine syndrome scores,AHI,the ratio of SaO_(2)<90%time/total sleep time,body mass index,and serum CRP,IL-8 in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The MSaO_(2) of the two groups was higher than that before treatment, and that of the observation group was higher than that of the control group, and the differences were statistically significant (P<0.05). Conclusion She medicine Shiliangcha Prescription combined with CPAP per nasal in the treatment of OSAHS and obesity patients with pattern of phlegm-damp congestion and excessiveness can effectively improve the signs and clinical symptoms.