长余辉纳米粒子的合成及其生物成像应用

Research Progress in Synthesis of Persistent Luminescence Nanoparticles and Their Applications in Bioimaging

长余辉发光是一种在激发停止后产生持久余辉发光的特殊光学现象,这种现象在防伪、信息或数据存储、光催化、传感和生物成像等领域中呈现出巨大的前景。长余辉纳米粒子(PLNPs)无需原位激发,能够减少组织的自发荧光和光散射干扰,被广泛用于生物成像领域。此外,发光性能可调节,且具有X射线激发、近红外区域长寿命发光或多模式成像特征的长余辉纳米探针能够应用于深层组织生物成像,为细胞或组织提供更为丰富的成像信息。该综述总结了近年来PLNPs的合成方法及其在生物成像应用中的最新研究进展,重点介绍了PLNPs在指纹成像、细胞和活体成像等方面的应用,同时还讨论了PLNPs在生物成像领域面临的挑战和未来的发展趋势。

Persistent luminescence is a unique optical phenomenon whereby luminescence remains after the stoppage of excitation.Persistent luminescence shows great promise in anticounterfeiting,information and data storage,photocatalysis,sensing,and bioimaging.Due to the absence of in-si-tu excitation,persistent luminescence nanoparticles(PLNPs)can efficiently eliminate autofluores-cence and light scattering interference and have been widely used in bioimaging.In addition,due to the tunable luminescence properties,PLNPs with features of X-ray excitation,long-lived near-infra-red emission or multi-mode imaging could facilitate deep tissue imaging,and provide abundant infor-mation on cells and tissues.In this review,the recent advances in the synthesis and bioimaging ap-plications of PLNPs were summarized,with focus on the usage of PLNPs in fingerprint imaging,cell imaging and in vivo imaging.We also discuss the challenges and perspectives of PLNPs in bioimaging.