刺激响应型SERS探针在分子医学领域的应用

Application of Stimuli-responsive SERS Probes in Molecular Medicine

在众多分子医学工具中,刺激响应型光学探针可根据特定的外部刺激改变其光学特性,提高检测的选择性和分辨率,为疾病的诊断、治疗、愈后监测提供了有力的支持。表面增强拉曼散射(SERS)光谱技术基于表面等离子共振原理,能够在纳米尺度上增强吸附在SERS基底上的分子的拉曼信号,显示出分子的结构信息,具有高准确度、多待测物同时检测的优点。大量研究表明,设计构建刺激响应型SERS(SR-SERS)探针,能够进一步提高检测的选择性和成像分辨率,同时利用靶向修饰和微创提取可获得检测对象有价值的实时信息,从而使该技术能够被广泛应用于分子医学领域。该文介绍了不同种类SR-SERS探针的基本原理和构建方法,就其近五年在分子医学领域的应用进展进行了概述,并对其在分子医学领域的发展趋势进行了讨论。

Among the various of molecular medical instruments,stimuli-responsive optical probes stand out due to their ability to alter their optical properties in response to specific external stimuli.This unique feature enhances the detection selectivity and resolution,making them a crucial compo-nent for improving disease diagnosis,treatment,and post-treatment monitoring.Surface-enhanced Raman scattering(SERS)spectroscopy technology,rooted in the principles of surface plasmon reso-nance,holds the power to amplify Raman signals from molecules adhering to nanoscale SERS sub-strates.This process not only unveils intricate molecular structural details but also touts technical ad-vantages like heightened precision and simultaneous detection of multiple targets.The wealth of re-search affirms that the strategic design and construction of stimuli-responsive SERS(SR-SERS)probes significantly elevate detection selectivity and imaging resolution.These probes,operating through minimally invasive and targeted means,furnish real-time invaluable insights.Consequently,they have gained substantial traction within the realm of molecular medicine.This paper presents di-verse variations of SR-SERS probes,elaborating on their underlying principles and construction methodologies.It provides a comprehensive overview of their recent advancements in the realm of mo-lecular medicine over the past half-decade,and engages in a discourse about the anticipated trajectory of SR-SERS probes in the sphere of molecular medicine.