甲泼尼龙琥珀酸钠对重症支原体肺炎患儿症状消失时间及炎症反应的影响

Effect of methylprednisolone sodium succinate on the time of symptom disappearance and inflammatory reaction in children with severe Mycoplasma pneumoniae pneumonia

目的研究甲泼尼龙琥珀酸钠对重症支原体肺炎(SMPP)患儿的治疗效果及安全性。方法采用随机数表法将南华大学附属长沙中心医院2021年1月—2022年12月收治的108例SMPP患儿分为两组,对照组(54例)采用常规治疗,研究组(54例)采用常规治疗联合甲泼尼龙琥珀酸钠治疗,比较2组临床疗效。结果治疗后研究组炎症因子水平低于对照组,肺功能指标、健康状况评分均高于对照组,发热、咳嗽、肺啰音及肺阴影消失时间均短于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论应用甲泼尼龙琥珀酸钠治疗可加快患儿症状缓解,改善机体炎症反应及肺功能,且安全性较高。

Objective To study the therapeutic effect and safety of methylprednisolone sodium succinate on children with severe Mycoplasma pneumoniae pneumonia(SMPP).Methods A total of 108 children with SMPP admitted to Changsha Central Hospital from January 2021 to December 2022 were divided into two groups by random number table method.The control group(54 cases)was treated with conventional therapy,and the study group(54 cases)was treated with conventional therapy combined with methylprednisolone sodium succinate.The clinical effects of the two groups were compared.Results After treatment,the levels of inflammatory factors in the study group were lower than those in the control group,and lung function indicators and health status scores were higher than those in the control group.The disappearance time of fever,cough,lung rales and lung shadows was shorter than that in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The application of methylprednisolone sodium succinate treatment can accelerate the relief of symptoms in children,improve the body’s inflammatory response and lung function,and has high safety.