普乐安治疗良性前列腺增生症用药依从性对疗效的影响

Influence of medication compliance on curative effect of Pule'an in the treatment of benign prostatic hyperplasia

目的探讨普乐安治疗良性前列腺增生症(BPH)用药依从性对疗效的影响。方法选取2022年8至12月绍兴市中心医院门诊收治的240例BPH患者为研究对象,均接受普乐安片单药治疗。按年龄(≤60岁为A组,>60岁为B组)、药物使用时长(≤3.5个月为C组,>3.5个月为D组)、药物使用密度(≤60.44%为E组,>60.44%为F组)、药物使用剂量分层(≤77.50%为G组,>77.50%为H组)进行分层分组,比较各分层分组患者治疗前后国际前列腺症状评分(IPSS)、生活质量评分(QoL)、最大尿流率(Q_(max)),采用Pearson相关或Spearman秩相关分析各分层参数与IPSS差值(ΔIPSS)、QoL差值(ΔQoL)、Q_(max)差值(ΔQ_(max))的相关性,采用多重线性回归模型分析各分层参数对ΔIPSS、ΔQoL、ΔQ_(max)的影响。结果不同年龄患者基线IPSS及治疗后IPSS比较,不同药物使用时长患者治疗后IPSS、治疗后QoL、ΔIPSS及ΔQoL比较,不同药物使用密度患者治疗后IPSS、治疗后QoL、ΔIPSS及ΔQoL比较,不同药物使用剂量患者治疗后IPSS、ΔIPSS及ΔQoL比较,差异均有统计学意义(均P<0.05)。药物使用时长、药物使用密度、药物使用剂量与ΔIPSS、ΔQoL、ΔQmax均呈正相关(均P<0.05),而患者年龄与ΔIPSS、ΔQoL、ΔQ_(max)均无相关性(均P>0.05)。多重线性回归方程为y_(1)=-4.881+0.069x_(1)+0.057x_(2)+0.213x_(3),y_(2)=-1.648+0.030x_(1)+0.066x_(2)+0.017x_(3),y_(3)=-4.299+0.087x_(1)+0.296x_(2)+0.049x_(3)(ΔIPSS、ΔQoL、ΔQ_(max)分别为x_(1)、x_(2)、x_(3),药物使用时长、药物使用密度、药物使用剂量分别为y_(1)、y_(2)、y_(3)),差异均有统计学意义(均P<0.05);对疗效的贡献度为药物使用时长>药物使用密度>药物使用剂量。结论普乐安用药依从性对BPH疗效有一定的影响,疗效贡献度从高到低分别为药物使用时长、药物使用密度、药物使用剂量。

Objective To Explore the influence of medication compliance on curative effect of Pule'an in the treatment of benign prostatic hyperplasia(BPH).Methods Two hundred and forty BPH patients admitted to the outpatient department of Shaoxing Central Hospital from August to December 2022 were selected as the study subjects,all of whom received single drug treatment with Pule'an tablets.Patients were stratified and grouped by age(≤60 years old as Group A,>60 years old as Group B),duration of drug use(≤3.5 months as Group C,>3.5 months as Group D),drug use density(≤60.44% as Group E,>60.44% as Group F),and drug dosage(≤77.50% as Group G,>77.50% as Group H),and their international prostate symptom score(IPSS),quality of life score(QoL),and maximum urine flow rate(Q_(max))in each stratified group were compared before and after treatment.Pearson correlation or Spearman tank correlation analysis was used to analyze the correlation between parameters of each stratified group and IPSS difference(ΔIPSS),QoL difference(ΔQoL),and Q_(max) difference(ΔQ_(max)).Multiple linear regression models were used to analyze the effect of parameters of each stratified group on ΔIPSS,ΔQoL and ΔQ_(max).Results There were significant differences between baseline IPSS and IPSS after treatment of patients with different ages,between IPSS,QoL after treatment and ΔIPSS,ΔQoL among patients with different drug use duration,between IPSS,QoL after treatment and ΔIPSS,ΔQoL among patients with different drug use densities,and between IPSS after treatment,ΔIPSS and ΔQoL among patients with different drug dosages(all P<0.05).The duration,density,and dosage of drug use were positively correlated with ΔIPSS,ΔQoL,and ΔQ_(max)(all P<0.05),while age showed no significant correlation with ΔIPSS,ΔQoL andΔQ_(max)(all P>0.05).The multiple linear regression equations were:y _(1)=-4.881+0.069x_(1)+0.057x_(2)+0.213x_(3),y_(2)=-1.648+0.030x_(1)+0.066x_(2)+0.017x_(3),y_(3)=-4.299+0.087x_(1)+0.296x_(2)+0.049x_(3)(ΔIPSS、ΔQoL、ΔQ_(max) as y_(1),y_(2),y_(3),drug usage duration,density,and dosage as x_(1),x_(2),x_(3)),and the differences were statistically significant(all P<0.05).The contribution to the therapeutic effect:drug use duration>drug use density>drug dosage.Conclusion Patients'compliance to Pule'an has a certain impact on the efficacy of BPH,and the order of the contribution to efficacy from high to low is drug usage duration,drug usage density and drug dosage.