血清骨钙素、骨硬化蛋白及骨膜蛋白水平与精神分裂症合并骨质疏松的关系研究

Relationship between serum osteocalcin,osteosclerosis protein,periosteum protein and osteoporosis in patients with schizophrenia

目的探讨血清骨钙素、骨硬化蛋白及骨膜蛋白水平与精神分裂症患者合并骨质疏松的关系。方法选取2022年1月至2023年1月在宁波市精神病院接受诊疗的98例精神分裂症患者为研究对象,根据骨密度测定结果分为骨质疏松组41例、骨量减少组23例、骨量正常组34例,比较3组患者血清骨钙素、骨硬化蛋白及骨膜蛋白水平,采用Pearson相关分析各项血清指标与精神分裂症患者骨密度的相关性,采用多因素logistic回归分析各项血清指标与精神分裂症合并骨质疏松的关系。结果不同骨密度患者血清骨钙素、骨硬化蛋白及骨膜蛋白水平比较,差异均有统计学意义(均P<0.05);其中骨质疏松组、骨量减少组血清骨钙素、骨硬化蛋白、骨膜蛋白水平均明显高于骨量正常组(均P<0.05),而骨质疏松组又均高于骨量减少组(均P<0.05)。血清骨钙素、骨硬化蛋白、骨膜蛋白水平与精神分裂症患者骨密度均呈正相关(r=0.498、0.387、0.265,均P<0.05)。血清骨钙素、骨硬化蛋白、骨膜蛋白水平均为精神分裂症患者合并骨质疏松的独立危险因素(OR=2.563、1.003、2.198,均P<0.05)。结论血清骨钙素、骨硬化蛋白、骨膜蛋白水平与精神分裂症患者骨密度均呈正相关,且是精神分裂症患者合并骨质疏松的独立危险因素。

Objective To investigate the relationship between serum osteocalcin,osteosclerosis protein,periosteum protein and osteoporosis in patients with schizophrenia.Methods Ninety-eight patients with schizo-phrenia diagnosed and treated in Ningbo Psychiatric Hospital from January 2022 to January 2023 were analyzed retrospectively.According to bone mineral density,they were divided into normal bone mass group(34 cases),reduced bone mass group(23 cases)and osteoporosis group(41 cases).The levels of serum osteocalcin,osteosclerosis protein and periosteum protein in all groups were compared.Pearson correlation was conducted to analyze the correlation between serum osteocalcin,osteossclerotin and periosteum protein and osteoporosis in schizophrenia patients.Multivariate logistic regression was used to analyze the relationship between serum indexes and schizophrenia complicated with osteoporosis.Results The levels of serum osteocalcin,osteosclerosis protein and periosteum protein among patients with different bone mineral density were significantly different(all P<0.05),of which,the reduced bone mass group and osteoporosis group had significantly higher levels than the normal bone mass group(all P<0.05),with those in the osteoporosis group higher than the reduced bone mass group(all P<0.05).Serum osteocalcin,osteosclerosis protein and periosteum protein were positively correlated with osteoporosis in schizophrenia patients(r=0.498,0.387,0.265,P=0.012,0.023,0.031,respectively).Multiple linear regression analysis showed that serum levels of osteocalcin,osteosclerosis protein and periosteum protein were independent risk factors for osteoporosis in patients with schizophrenia(OR=2.563,1.003,2.198,all P<0.05).Conclusion Serum levels of osteocalcin,osteosclerosis protein and periosteum protein are positively correlated with bone mineral density in patients with schizophrenia,and are independent risk factors for osteoporosis in patients with schizophrenia.