草酸艾司西酞普兰治疗对慢性乙肝患者焦虑抑郁状态的影响

Effect of Escitalopram Oxalate on Anxiety and Depression in Patients with Chronic Hepatitis B

目的观察草酸艾司西酞普兰治疗对慢性乙型肝炎患者焦虑抑郁状态的影响。方法选择某院2020年7月~2022年7月于门诊就诊的60位慢性乙肝患者为研究对象,采用随机数字表法分成对照组与治疗组,每组30名。对照组给予常规护肝、抗病毒等治疗,同时进行心理干预及健康教育,治疗组在上述治疗方法上使用草酸艾司西酞普兰治疗,均连续治疗12周。记录治疗期间是否发生不良反应,比较患者治疗前后血清脑源性神经营养因子(BDNF)、去甲肾上腺素(NE)水平及5-羟色胺(5-HT)水平,采用汉密尔顿焦虑、抑郁量表(HAMA、HAMD)评估患者负性情绪,采用乙肝患者特异性生活质量量表(QLS-CHB)评估患者生活质量。结果治疗12周后,治疗组血清BDNF、NE及5-HT水平及QLS-CHB评分均高于对照组(均P<0.05),HAMA评分及HAMD评分均低于对照组(均P<0.05),两组治疗期间不良反应出现率对比差异无统计学意义(P>0.05)。结论草酸艾司西酞普兰治疗对于改善慢性乙肝患者焦虑和抑郁状态方面效果较好,可以提升其生活质量。

OBJECTIVE To observe the effect of escitalopram oxalate on anxiety and depression in patients with chronic hepatitis B(CHB).METHODS Sixty patients with chronic hepatitis B who were treated in the outpatient department of Fuzhou First People's Hospital from July 2020 to July 2022 were selected as the research objects.They were divided into control group and treatment group by random number table method,with 30 patients in each group.The control group was given routine liver protection,antiviral treatment,psychological intervention and health education,while the treatment group was treated with escitalopram oxalate on the basis of the above treatment methods.Both groups were treated continuously for 12 weeks.Adverse reactions were recorded during the treatment.The levels of serum brain-derived neurotrophic factor(BDNF),norepinephrine(NE)and 5-hydroxytryptamine(5-HT)were compared before and after treatment.The Hamilton Anxiety and Depression Scale(HAMA and HAMD)were used to evaluate the negative emotions of patients.The quality of life of patients was evaluated by the hepatitis B specific quality of life scale(QLS-CHB).RESULTS After 12 weeks of treatment,the levels of serum BDNF,NE and 5-HT and QLS-CHB score in the treatment group were higher than those in the control group(all P<0.05),and the HAMA score and HAMD score were lower than those in the control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).CONCLUSION Escitalopram oxalate is effective in improving anxiety and depression in patients with chronic hepatitis B,and can improve their quality of life.