托莫西汀与阿立哌唑对注意缺陷多动障碍儿童冲动行为及认知功能的影响

Effects of Tomoxetine and Aripiprazole on Impulsive Behavior and Cognitive Function in Children with Attention Deficit Hyperactivity Disorder

目的:比较托莫西汀与阿立哌唑对注意缺陷多动障碍儿童冲动行为及认知功能的影响。方法:选取2020年7月—2022年12月宜春市第三人民医院收治的102例注意缺陷多动障碍患儿,采用随机数字表法分为研究组(给予托莫西汀治疗)和对照组(给予阿立哌唑治疗),每组51例。两组连续治疗1个月后评价治疗效果。对比两组联合型瑞文测验(CRT)评分、蒙特利尔认知功能评估量表(MoCA)评分、临床效果、不良反应。结果:治疗后,两组比较推理能力、类同比较能力、知觉辨别能力、系列关系能力、抽象推理能力、智商数评分较治疗前均升高,差异均有统计学意义(P<0.05),且研究组均高于对照组(P<0.05)。治疗前,两组MoCA评分对比,差异无统计学意义(P>0.05);治疗后,两组MoCA评分较治疗前均升高,差异均有统计学意义(P<0.05),且研究组高于对照组,差异有统计学意义(P<0.05)。研究组临床疗效优于对照组(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:与阿立哌唑相比,托莫西汀治疗注意缺陷多动障碍患儿可有效提升综合能力,减少冲动行为,提高认知功能及临床疗效,降低不良反应发生率。

Objective:To compare the effects of Tomoxetine and Aripiprazole on impulsive behavior and cognitive function in children with attention deficit hyperactivity disorder.Method:A total of 102 children with attention deficit hyperactivity disorder admitted to the Third People's Hospital of Yichun from July 2020 to December 2022 were selected,and divided into study group(treated with Tomoxetine)and control group(treated with Aripiprazole)by random number table method,with 51 cases in each group.The effect of treatment was evaluated after 1 month of continuous treatment.The combined Raven's test(CRT)score,the Montreal cognitive function assessment scale(MoCA)score,the clinical efficacy,and the adverse reactions were compared between the two groups.Result:After treatment,comparative reasoning ability,similar comparison ability,perceptual discrimination ability,series relationship ability,abstract reasoning ability,and IQ number scores of both groups were increased compared to those before treatment,the differences were statistically significant(P<0.05),and those in the study group were higher than those in the control group(P<0.05).Before treatment,there was no statistical difference in MoCA score between the two groups(P>0.05);after treatment,MoCA scores of both groups were increased compared to those before treatment,the differences were statistically significant(P<0.05),and that in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).The clinical efficacy of the study group was better than that of the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Compared with Aripiprazole,Tomoxetine can effectively improve comprehensive ability,reduce impulsive behavior,improve cognitive function and clinical efficacy,and reduce the incidence of adverse reactions in children with attention d eficit hyperactivity disorder.