基于免疫调控及内分泌机制探讨寿胎丸辅助治疗先兆流产的作用

Study on the Effect of Shoutai Pills in Adjuvant Treatment of Threatened Abortion Based on Immune Regulation and Endocrine Mechanism

目的:基于免疫调控及内分泌机制探讨寿胎丸辅助治疗先兆流产的作用。方法:回顾性选取2020年5月—2022年5月江西中医药大学第二附属医院收治的先兆流产患者90例,根据治疗方案分为寿胎丸组(n=43)和常规组(n=47)。常规组予以口服地屈孕酮联合肌注绒促性素治疗,寿胎丸组在常规组的治疗基础上口服寿胎丸。比较两组免疫调控指标和内分泌指标水平,并对综合疗效和中医证候疗效进行评定。结果:寿胎丸组综合疗效、中医证候疗效(90.70%、88.37%)均显著高于常规组(65.96%、61.70%),差异均有统计学意义(P<0.05);治疗后,寿胎丸组CD4^(+)明显高于常规组,CD8^(+)显著低于常规组,差异均有统计学意义(P<0.05);治疗后,寿胎丸组雌二醇(E_(2))和人绒毛膜促性腺素(β-hCG)水平均显著高于常规组,差异均有统计学意义(P<0.05)。结论:寿胎丸辅助治疗先兆流产的效果显著,可能通过影响免疫调控和内分泌功能起作用。

Objective:To analyze the effect of Shoutai Pills in adjuvant treatment of threatened abortion based on immune regulation and endocrine mechanism.Method:A total of 90 patients with threatened abortion admitted to the Second Affiliated Hospital of Jiangxi University of CM from May 2020 to May 2022 were retrospectively selected and divided into Shoutai Pills group(n=43)and conventional group(n=47)according to the treatment protocol.The conventional group was treated with oral Dydrogesterone combined with intramuscular injection of Chorionic Gonadotrophin,and the Shoutai Pills group was treated with oral Shoutai Pills on the basis of the conventional group.The levels of immune regulation indexes and endocrine indexes were compared between the two groups,and the comprehensive efficacy and TCM syndrome efficacy were evaluated.Result:The comprehensive efficacy and TCM syndrome efficacy of Shoutai Pills group(90.70%,88.37%)were significantly higher than those of conventional group(65.96%,61.70%),the differences were statistically significant(P<0.05).After treatment,CD4^(+)in Shoutai Pills group was significantly higher than that in conventional group,and CD8^(+)in Shoutai Pills group was significantly lower than that in conventional group,the differences were statistically significant(P<0.05).After treatment,the levels of estradiol(E_(2))and human chorionic gonadotropin(β-hCG)in Shoutai Pills group were significantly higher than those in conventional group,the differences were statistically significant(P<0.05).Conclusion:The effect of Shoutai pills in adjuvant treatment of threatened abortion is significant,which may play a role by affecting immune regulation and endocrine function.