2型糖尿病患者体重指数与血清补体C1q的相关性研究

Association of body mass index and serum complement C1q in patients with type 2 diabetes mellitus

目的探讨2型糖尿病(T_(2)DM)患者体重指数与血清补体C1q的关系。方法收集2019年1—12月于陕西省人民医院内分泌科住院的119例T_(2)DM患者的基本信息、人体测量参数和生化参数,根据体重指数将研究对象分为对照组(<24 kg/m^(2),56例)和观察组(≥24 kg/m^(2),63例)。比较2组患者血清补体C1q等指标的差异,分析体重指数与各临床指标的相关性。采用受试者工作特征曲线分析血清补体C1q水平预测T_(2)DM患者体重指数≥24 kg/m^(2)的价值。结果观察组血清补体C1q水平高于对照组[(185±41)mg/L比(171±33)mg/L],差异有统计学意义(P<0.05)。体重指数与身高、体质量、腰围、臀围、腰臀比、γ-谷氨酰转肽酶、胆碱酯酶、白蛋白、三酰甘油、血磷、血尿酸、补体C1q呈正相关,与年龄、血尿素氮、血氯呈负相关(P<0.01或P<0.05)。血清补体C1q预测T_(2)DM患者体重指数≥24 kg/m^(2)的最佳截断值为183.8 mg/L,曲线下面积为0.600(95%置信区间:0.498~0.701),敏感度为67.9%,特异度为52.4%。结论T_(2)DM患者体重指数与血清补体C1q水平呈正相关,血清补体C1q可能参与了T_(2)DM患者体重指数升高的发生及发展过程。

Objective To investigate the relationship between body mass index(BMI)and serum complement C1q in patients with type 2 diabetes mellitus(T_(2)DM).Methods The basic information,anthropometric parameters and biochemical parameters of 119 patients with T_(2)DM admitted to Department of Endocrinology,Shaanxi Provincial People′s Hospital from January to December 2019 were collected.According to BMI level,subjects were divided into control group(BMI<24 kg/m^(2),56 cases)and observation group(BMI≥24 kg/m^(2),63 cases).The differences of serum complement C1q and other indexes between the two groups were compared.The correlation between BMI and clinical indexes was analyzed.Receiver operating characteristic curve was used to analyze the value of serum complement C1q levels in predicting BMI≥24 kg/m^(2)in T_(2)DM patients.Results The level of C1q in observation group was significantly higher than that in control group[(185±41)mg/L vs(171±33)mg/L](P<0.05).BMI was positively correlated with height,body mass,waist circumference,hip circumference,waist-to-hip ratio,γ-glutamyl transpeptidase,cholinesterase,albumin,triacylglycerol,blood phosphorus,blood uric acid,and complement C1q,and was negatively correlated with age,blood urea nitrogen and blood chlorine(P<0.05 or P<0.01).The optimal cutoff value for predicting BMI≥24 kg/m^(2)in T_(2)DM patients with serum complement C1q was 183.8 mg/L,the area under the curve was 0.600(95%confidence interval:0.498-0.701),the sensitivity was 67.9%,and the specificity was 52.4%.Conclusion There is a positive correlation between BMI and serum complement C1q level in T_(2)DM patients,suggesting that serum C1q may be involved in the occurrence and development of BMI increase in T_(2)DM patients.