普萘洛尔联合聚桂醇治疗不同分型血管瘤患儿的临床效果比较

Comparative on the clinical effect of propranolol combined with lauromacrogol on pediatric patients with different patterns of hemangioma

目的观察口服普萘洛尔联合局部注射聚桂醇治疗不同分型血管瘤患儿的临床效果。方法回顾性分析2020年1月至2022年1月在首都儿科研究所附属儿童医院接受治疗的88例血管瘤患儿的临床资料。根据血管瘤发生部位的深度不同分为浅表组(30例)、深部组(28例)和混合组(30例)。比较3组患儿治疗6个月的总有效率及不良反应发生情况,并比较治疗前及治疗6个月后3组患儿的血管指数、血流指数和血管-血流指数的变化。结果治疗6个月后,3组患儿的临床疗效等级分布及总有效率比较差异均有统计学意义(均P<0.05),其中浅表组的总有效率高于深部组[96.7%(29/30)比75.0%(21/28)],差异有统计学意义(P<0.05)。治疗6个月后3组患儿的血管指数、血流指数及血管-血流指数均较治疗前降低,且浅表组和混合组患儿以上指标水平明显低于深部组,差异均有统计学意义(均P<0.05)。浅表组、深部组和混合组不良反应发生率分别为20.0%(6/30)、32.1%(9/28)、23.3%(7/30),3组间差异无统计学意义(χ^(2)=1.206,P=0.547)。结论口服普萘洛尔联合局部注射聚桂醇治疗血管瘤患儿的效果良好,其中治疗浅表型血管瘤的效果明显优于深部型。

Objective To observe the clinical effect of oral propranolol combined with local injection of lauromacrogol on pediatric patients with different patterns of hemangioma.Methods Clinical data of 88 children with hemangiomas treated at Children′s Hospital,Capital Institute of Pediatrics from January 2020 to January 2022 were collected and retrospectively analyzed.They were divided into superficial group(30 cases),deep group(28 cases),and mixed group(30 cases)based on the depth of the site where the hemangioma occurred.The total effective rate and adverse reactions of three groups of children after 6 months of treatment were compared,and the changes in vascular index,blood flow index,and vascular flow index were compared before and after 6 months of treatment.Results After 6 months of treatment,there were statistically significant differences in the distribution of clinical efficacy levels and total effective rate among the three groups of children(all P<0.05).The total effective rate of the superficial group was higher than that of the deep group[96.7%(29/30)vs 75.0%(21/28)],with a statistically significant difference(P<0.05).After 6 months of treatment,the vascular index,blood flow index,and vascular flow index of the three groups of children decreased compared to before treatment,and the levels of these indicators in the superficial and mixed groups of children were significantly lower than those in the deep group,with statistical significance(all P<0.05).The incidence of adverse reactions in the superficial group,deep group,and mixed groups was 20.0%(6/30),32.1%(9/28),and 23.3%(7/30),respectively,with no statistically significant difference among the three groups(χ^(2)=1.206,P=0.547).Conclusions Oral propranale combined with local injection of lauromacrogol has a good therapeutic effect on pediatric patients with hemangiomas,with the treatment effect for superficial hemangiomas being significantly better than that for deep hemangiomas.