半夏莪术消痞汤治疗脾胃湿热型慢性非萎缩性胃炎临床研究及对胃肠激素水平的影响

Clinical Study on Treatment of Chronic Non-Atrophic Gastritis of Spleen-Stomach Damp-Heat Type with Banxia Ezhu Xiaopi Decoction(半夏莪术消痞汤)and Its Effect on Gastrointestinal Hormone Levels

目的探讨半夏莪术消痞汤治疗脾胃湿热型慢性非萎缩性胃炎(chronic non-atrophic gastritis,CNAG)的效果及对胃肠激素水平的影响。方法选取2021年1月—2021年7月该院320例脾胃湿热型Hp感染CNAG患者,随机数字表法分为观察组与对照组,每组各160例患者,对照组给予常规西医治疗,观察组在对照组的基础上给予半夏莪术消痞汤,两组均持续治疗14d,比较两组临床疗效、Hp清除率、内镜积分及病理组织学积分、胃肠激素及氧化应激指标水平。结果观察组临床治疗有效率90.00%(144/160)高于对照组81.88%(131/160)(P<0.05);观察组Hp转阴率76.88%(123/160)高于对照组64.38%(103/160)(P<0.05);观察组治疗后内镜检查黏膜红斑、黏膜糜烂、黏膜出血积分以及病理组织学慢性炎症、活动性炎症积分低于对照组(P<0.05);观察组治疗后胃脘疼痛、脘腹痞胀、口黏且苦、泛恶、纳呆、身重困倦、大便黏滞不爽证候积分低于对照组(P<0.05);观察组治疗后血浆胃动素(MOT)、促胃液素(GAS)、胃蛋白酶原Ⅰ(PGⅠ)及PGⅠ/PGⅡ比值水平高于对照组(P<0.05);观察组治疗后丙二醇(MDA)水平低于对照组,超氧化物歧化酶(SOD)水平高于对照组(P<0.05)。结论在常规西医治疗的基础上,联合使用半夏莪术消痞汤治疗CNAG可有效减轻患者临床症状,提高Hp清除率,调节胃肠激素水平,减轻氧化应激。

Objective To investigate the effect of Banxia Ezhu Xiaopi Decoction(半夏莪术消痞汤)on chronic non-atrophic gastritis(CNAG)of spleen-stomach damp-heat type and its effect on gastrointestinal hormone levels.Methods From January 2021 to July 2021,320 patients with CNAG infection with H.pylori(Hp)in the spleen-stomach damp-heat type were selected and randomly divided into an observation group and a control group,with 160 patients in each group.The control group was given conventional western medicine treatment,and the observation group was given Banxia Ezhu Xiaopi Decoction on the basis of the control group.Both groups were treated continuously for 14 days.The clinical efficacy,Hp clearance rate,endoscopic and his-topathological scores,gastrointestinal hormones and oxidative stress index levels were compared between the two groups.Results The effective rate of clinical treatment in the observation group was 90.00%,which was higher than 81.88%in the control group(P<0.05).The negative rate of Hp in the observation group was 76.88%,which was higher than 64.38%in the control group(P<0.05).After treatment,the endoscopic scores of mucosal erythema,mucosal erosion,mucosal hemorrhage and histopatholog-ical chronic inflammation and active inflammation scores in the observation group were lower than those in the control group(P<0.05).After treatment,the syndrome scores of epigastric pain,epigastric distention,sticky and bitter mouth,generalized nausea,anorexia,drowsiness and sticky stool in the observation group were lower than those in the control group(P<0.05).After treat-ment,the levels of plasma motilin(MOT),gastrin(GAS),pepsinogen I(PGⅠ)and PGⅠ/PGⅡratio in the observation group were higher than those in the control group(P<0.05).After treatment,the level of propylene glycol(MDA)in the observation group was lower than that in the control group,and the level of superoxide dismutase(SOD)was higher than that in the control group(P<0.05).Conclusion On the basis of conventional western medicine treatment,combined use of Banxia Ezhu Xiaopi De-coction in the treatment of CNAG can effectively relieve the clinical symptoms of patients,improve the clearance rate of Hp,regu-late the levels of gastrointestinal hormones and reduce the oxidative stress.