复方丹参滴丸联合降压常规疗法对老年冠心病稳定性心绞痛及血清CRP的影响

Effect of Compound Danshen Dropping Pills(复方丹参滴丸)Combined with Conventional Antihypertensive Therapy on Hypersensitive C-reactive Protein in Elderly Patients with Stable Angina Pectoris Caused by Coronary Heart Disease

目的研究复方丹参滴丸联合降压常规疗法对老年冠心病稳定性心绞痛C反应蛋白(C-reactive protein,CRP)的影响。方法回顾性分析2020年3月—2021年9月攀枝花市学院附属医院接诊的共100例符合纳入表的患者的临床资料。将所有患者按治疗方法的差异分为研究组与对照组,各50例。对照组患者给予降压常规疗法进行治疗,研究组给予复方丹参滴丸联合降压常规疗法进行治疗。治疗3个月后比较分析两组患者的治疗效果,治疗前后的炎性因子水平[CRP、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α]、氧化应激指标[超氧化物歧化酶(superoxide dismutase,SOD)、三羧酸(tricarboxylic acid,TAC)、丙二醛(malondialdehyde,MDA)]、不良反应发生率。结果研究组治疗总有效率与对照组相比明显偏高(P<0.05)。治疗前研究组患者的CRP、IL-6和TNF-α水平与对照组比较差异无统计学意义(P>0.05)。治疗后,两组患者的CRP、IL-6和TNF-α水平显著降低,研究组患者的CRP、IL-6、TNF-α水平低于对照组(P<0.05)。研究组治疗前SOD、TAC、MDA水平与对照组比较差异无统计学意义(P>0.05)。两组患者治疗后的SOD、TAC水平均明显升高,MDA水平明显降低,且研究组SOD、TAC水平与对照组相比明显偏高,MDA水平与对照组相比明显偏低(P<0.05)。研究组不良反应总发生率与对照组比较差异无统计学意义(P>0.05)。结论复方丹参滴丸联合降压常规疗法治疗老年冠心病稳定性心绞痛患者,使得患者CRP的水平明显降低,有较为显著的治疗效果。

Objective To study the effect of Compound Danshen Dropping Pills(复方丹参滴丸)combined with conventional antihypertensive therapy on C-reactive protein(CRP)in elderly patients with stable angina pectoris.Methods The clinical data of 100 patients with coronary heart disease and angina pectoris treated in the hospital from March 2020 to September 2021 was analyzed retrospectively.According to different treatment methods,all patients were divided into study group and control group,with 50 cases in each group.The control group was treated with conventional antihypertensive therapy,and the study group was treated with Compound Danshen Dropping Pills combined with conventional antihypertensive therapy.After 3 months of treatment,the treatment effects,inflammatory factor levels[CRP,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],oxidative stress indexes[superoxide dismutase(SOD),tricarboxylic acid(TAC),malondialdehyde(MDA)]and the incidence of adverse reactions of the two groups were compared and analyzed.Results The total effective rate of the study group was significantly higher than that of the control group(P<0.05).The levels of CRP,IL-6 and TNF-αin the study group and control group before treatment had no significant difference(P>0.05).After treatment,the levels of CRP,IL-6 and TNF-αin the two groups decreased and those levels in the study group was significantly lower than those of the control group(P<0.05).The levels of SOD,TAC and MDA in the two groups before treatment had no significant difference(P>0.05).After treatment,the levels of SOD and TAC in the two groups were significantly increased,while the levels of MDA were significantly decreased.The levels of SOD and TAC in the study group were significantly higher than those in the control group,and the level of MDA was significantly lower than that in the control group(P<0.05).The total incidence of adverse reactions in the study group was compared with that in the control group(P>0.05).Conclusion Compound Danshen Dropping Pills combined with conventional antihypertensive therapy can significantly reduce the level of CRP in elderly patients with stable angina pectoris.