硫辛酸联合胰激肽原酶针治疗糖尿病足溃疡并发感染的临床效果观察

Observation on the Clinical Effect of Lipoic Acid Combined with Pancreatic Kininogenase Needle in the Treatment of Diabetic Foot Ulcers Complicated with Infection

目的探讨硫辛酸联合胰激肽原酶针治疗糖尿病足溃疡并发感染的临床效果。方法选取2020年9月至2023年7月我院收治的80例糖尿病足溃疡并发感染患者,随机分为两组各40例。两组患者均予以常规用药治疗。对照组应用硫辛酸治疗,观察组在对照组基础上采用胰激肽原酶针治疗。比较两组患者的临床疗效、血清炎性因子水平、不良反应发生率。结果观察组治疗总有效率为92.50%,高于对照组的67.50%(P<0.05)。治疗后,两组血清TNF-α、CRP水平均降低,且观察组TNF-α、CRP水平低于对照组(P<0.05)。两组的不良反应发生率比较无统计学差异(P>0.05)。结论硫辛酸联合胰激肽原酶针治疗糖尿病足溃疡并发感染,可提高临床疗效,且不会明显增加药物不良反应。

Objective To analyze the clinical effect of lipoic acid combined with pancreatic kininogenase needle in the treatment of diabetic foot ulcers complicated with infection.Methods 80 patients with diabetic foot ulcers complicated with infection admitted to our hospital from September 2020 to July 2023 were selected and randomly divded into two groups,with 40 cases in each group.Both groups received conventional treatment.The control group was treated with lipoic acid,and the observation group was treated with lipoic acid combined with pancreatic kininogenase needle.The clinical efficacy,serum inflammatory factors,and incidence of adverse reactions were compared between groups.Results The total effective rate of treatment in the observation group was 92.50%,higher than 67.50%in the control group(P<0.05).After treatment,the serum TNF-αand CRP levels of the two groups decreased,and the serum TNF-αand CRP levels of the observation group were lower than those of the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between two groups(P>0.05).Conclusions Lipoic acid combined with pancreatic kininogenase needle in the treatment of diabetic foot ulcers complicated with infection can effectively improve the clinical efficacy without increasing obvious adverse reactions.