Nrf2信号通路作为虾青素治疗新靶点的研究进展

Research progress of Nrf2 signaling pathway as a new target for astaxanthin therapy

虾青素是一种多靶点脂溶性酮式类胡萝卜素,因其丰富的生物活性,特别是其强大的抗氧化能力而广受关注。虾青素具有抗氧化、抗炎、抗糖尿病、神经保护等多种生物活性作用,但虾青素这些治疗作用的分子机制尚不完全清楚。其中,核因子E2相关因子2(nuclear factor erythroid-2 related factor 2,Nrf2)信号通路是虾青素发挥作用的重要信号通路之一。Nrf2信号通路是细胞抗氧化应激的主要调节因子,它调节了氧化还原稳态以及细胞解毒相关基因的表达。本文综述了虾青素激活Nrf2信号通路的作用机制及其在各种疾病中的保护作用。

Astaxanthin is a multi-targeted fat-soluble ketocarotenoid,and has attracted much attention in recent years because of its abundant biological activity,especially its powerful antioxidant capacity.Astaxanthin has a variety of biological activities,such as antioxidant,anti-inflammatory,anti-diabetic,neuroprotective,and other effects.However,the molecular mechanisms of these therapeutic effects of astaxanthin are not fully understood,and the nuclear factor erythroid-2 related factor 2(Nrf2)signaling pathway is one of the important signaling pathways of astaxanthin.The Nrf2 signaling pathway is a major regulator of cellular resistance to oxidative stress,and it regulates redox homeostasis as well as the expression of genes involved in cellular detoxification.This article reviews the mechanism of astaxanthin activating the Nrf2 signaling pathway and its protective effect in various diseases.