肺表面活性物质治疗新生儿急性呼吸窘迫综合征的研究进展

A Review of Pulmonary Surfactant in Treating Neonatal Acute Respiratory Distress Syndrome

新生儿急性呼吸窘迫综合征(nARDS)是新生儿期严重疾病之一,严重危害新生儿健康,其主要治疗手段包括呼吸机辅助通气、PS替代、抗感染及营养支持等。PS的替代治疗是新生儿急性呼吸窘迫综合征的独特治疗方式之一,PS的使用能显著改善患儿的低氧血症和呼吸窘迫。本文就nARDS的治疗过程中,PS的种类、剂量、给药途径、给药时机、重复给药等方面作一综述。

Neonatal acute respiratory distress syndrome(nARDS)is one of the serious diseases in the neonatal period,which seriously harms the health of newborns.The main treatment methods include ventilator-assisted ventilation,PS replacement,anti-infection and nutritional support,etc.The alternative treatment of PS is one of the unique treatment methods of nARDS,and the use of PS can significantly improve hypoxemia and respiratory distress in neonates.This paper reviewed the types,dosage,administration route,administration time,and repeated administration of PS in the treatment of nARDS.