乌龙茶对动脉硬化的保护作用:一项3.4年的随访研究

Protective effect of Oolong tea on arterial stiffness:a 3.4-year follow-up study

目的探讨乌龙茶与动脉硬化之间的关系。方法采用整群随机方法,在福建省武夷山市的54个社区中抽取4个社区,对入组的4358人在基线状态和平均3.4年后随访各测量一次臂踝动脉脉搏波传导速度(baPWV)和踝臂血压指数(ABI),通过广义估计方程的单变量和多变量分析饮茶量、饮茶时间以及饮茶量和时间的交互作用是否与baPWV和ABI存在相关性。结果与不饮乌龙茶人群对比,饮乌龙茶人群在基线和随访时有更低的baPWV[基线:(1423.4±347.3)比(1551.6±345.5)cm/s,t=11.09,P<0.01;随访,(1433.2±339.4)比(1567.8±365.5),t=11.63,P<0.01]。与基线对比,饮乌龙茶的人群在随访时baPWV和ABI的变化无统计学意义(均P>0.05),而不饮乌龙茶人群在随访时有更高的baPWV和ABI(均P<0.05)。多变量广义估计方程(GEE)分析显示,相对于饮乌龙茶10年以下,饮乌龙茶10年及以上可以有效降低发生高ABI(>1.4)、高baPWV(≥1400 cm/s)的风险,后者分别是前者的0.955倍(P=0.003)、0.939倍(P=0.035)。相对于饮20 g/d以下,饮≥20 g/d可以有效降低发生高ABI、高baPWV的风险,后者分别是前者的0.932倍(P<0.001)、0.933倍(P=0.038)。结论乌龙茶可能有助于预防动脉硬化,特别是饮用10年以上且≥20 g/d的人群。

Objective To explore the association between Oolong tea and arterial stiffness.Methods Four communities were selected from 54 communities in Wuyishan City,Fujian Province by cluster random method,brachialankle artery pulse wave velocity(baPWV)and ankle-arm blood pressure index(ABI)were measured once at baseline status and once at follow-up after a mean of 3.4 years for each of the 4358 individuals enrolled,and univariate and multivariate analyses by generalized estimating equations were performed to determine whether the amount of tea consumed,the time of tea consumed,and the amount and time of tea consumed interaction were associated with baPWV and ABI.Results Compared with non-drink Oolong tea population,Oolong tea drinkers had lower baPWV at baseline[(1423.4±347.3)vs(1551.6±345.5)cm/s,t=11.09,P<0.01]and follow-up[(1433.2±339.4)vs(1567.8±365.5),t=11.63,P<0.01].Compared with baseline,there was no significant change of baPWV and ABI at follow-up in Oolong tea drinkers(both P>0.05),but baPWV and ABI were higher in follow-up in non-drink Oolong tea population(both P<0.05).Multivariate generalized estimating equation(GEE)analysis showed that compared with drinking Oolong tea for less than 10 years,drinking Oolong tea for 10 years or more could effectively reduce the risk of high ABI(>1.4)and high baPWV(≥1400 cm/s),which was 0.955 times(P=0.003)and 0.939 times(P=0.035),respectively.Compared with drinking below 20 g/d,drinking 20 g/d or more effectively reduced the risk of high ABI and high baPWV,which was 0.932 times(P<0.001)and 0.933 times(P=0.038),respectively.Conclusion Oolong tea may have a protective effect against arterial stiffness,especially in those who habitually consume tea for more than 10 years and 20 g/d.