饮茶对血压影响的荟萃分析与系统评价

Effects of tea drinking on blood pressure:a systematic review and meta-analysis

目的 运用荟萃分析的方法系统评价饮茶对血压的影响。方法 通过PubMed、EMbase、Web of Science、the Cochrane Library、中国知网、万方以及中国生物医学文献数据库,检索到截至2023年2月发表的有关饮茶对血压影响的随机对照研究,运用Stata软件对所有纳入文献的结局性指标进行统计分析,采用Egger’s检验对纳入文献进行发表偏倚风险评估。结果 本研究总共纳入16篇文献,涉及受试者1 060人。荟萃分析结果显示,与对照组相比,饮茶显著降低收缩压[加权均数差(WMD):-2.16 mmHg;95%CI-3.27~-1.05 mmHg;P<0.01]和舒张压(WMD:-2.36 mmHg;95%CI-3.29~-1.43 mmHg;P<0.01)。荟萃回归分析显示,饮茶降压效果与饮用时长相关。亚组分析表明,较长饮用时间(2月或以上)可以降低收缩压(WMD:-3.03 mmHg;95%CI-4.52~-1.54 mmHg;P<0.01)及舒张压(WMD:-3.90 mmHg;95%CI-5.01~-2.80 mmHg;P<0.01),且各研究间的异质性低(I2<50%)。敏感性分析显示,单项研究缺失对最终结果无显著影响。结论 饮茶可降低收缩压和舒张压,适当延长饮用时间可以增加其降压效果。

Objective A meta-analysis was used to systematically evaluate the effect of tea consumption on blood pressure.Methods Searched pubMed,EMbase,Web of Science,the Cochrane Library,China Knowledge Network,Wanfang,and the Chinese Biomedical Literature Database for randomised controlled studies on the impact of tea consumption on blood pressure published up to February 2023.All included literature was statistically analyzed for outcome indicators using Stata software,and the risk of publication bias was assessed for the included literature using Egger's test.Results A total of 16 reports involving 1060 subjects were included.The meta-analysis found that tea consumption significantly reduced systolic blood pressure(SBP)(WMD:-2.16 mmHg;95%CI:-3.27 to-1.05 mmHg;P<0.01)and diastolic blood pressure(DBP)(WMD:-2.36 mmHg;95%CI:-3.29 to-1.43 mmHg;P<0.01)when compared to the control group.Meta-regression analysis showed that the antihypertensive effect of tea consumption was associated with duration of consumption,and subgroup analysis revealed that a longer duration of consumption(≥2 months)reduced SBP(-3.03 mmHg;95%CI:-4.52 to-1.54 mmHg;P<0.01)and DBP(-3.90 mmHg;95%CI:-5.01 to-2.80 mmHg;P<0.01),with low heterogeneity between studies(I2<50%).Sensitivity analysis revealed that the absence of a single study had no significant effect on the final results.Conclusion Tea consumption can lower SBP and DBP,and appropriate extension of drinking duration can boost its antihypertensive effect.