摘要
More than 170 distinct chemical modifications have been identified in non-coding and coding RNAs.Accumulating evidence suggests that RNA modifications play pivotal roles at both the molecular and physiological levels.Dysregulation of RNAmodifying enzymes has been linked to various human cancers and developmental diseases.The expanding understanding of RNA modifications in molecular and cellular functions further suggests promising prospects for therapeutic applications.Recently,the creation of effective mRNA vaccines against coronavirus disease 2019(COVID-19),based on RNA base modification,was honored with the Nobel Prize in Physiology or Medicine 2023(https://www.nobelprize.org/prizes/medicine/2023/press-release/).Aiming to provide a forum for emerging advances in detection and functional studies of epitranscriptomic modifications,we have organized a special issue"RNA Modifications and Epitranscriptomics"for the journal Genomics,Proteomics&Bioinformatics(GPB).This special issue encompasses a wide range of topics,including:(1)dynamic landscapes of RNA modifications in various organisms,including animals,plants,and viruses;(2)mechanistic regulation of m^(6)A and m5 C modifications in human diseases and plant responses to stresses;(3)an online platform for unveiling the context-specific m^(6)A methylation and m^(6)Aaffecting mutation;and(4)the regulatory role of non-coding RNAs(ncRNAs),including tRNAs and circular RNAs(circRNAs),in gene expression regulation.
