慢性内脏痛及诱发负性情绪的神经回路研究进展

Research progress on neural circuits of negative emotions induced by chronic visceral pain

慢性内脏痛及其诱发的负性情绪严重影响了病人的生活质量,并产生巨大的社会经济负担。然而,与其相关的神经回路和机制仍是尚未解决的生命科学难题。前扣带回和杏仁核是处理啮齿类动物和人类慢性疼痛感觉和情绪成分的核心脑区,因此,本文以慢性内脏痛中功能性胃肠疾病(肠易激综合征)为例,重点围绕上述核团,从神经回路水平,总结并分析肠易激综合征啮齿类动物模型内脏痛及诱发负性情绪脑回路的最新发现。同时还讨论了今后该研究领域相关的重要研究方向,为揭示慢性内脏痛及诱发负性情绪的机制研究提供新线索。

Chronic visceral pain and its induced negative emotions reduce the quality of life of sufferers and have large socioeconomic costs.However,the neural circuits and mechanisms associated with it remain unsolved challenges in life sciences.Anterior cingulate cortex and amygdala are the core brain regions responsible for processing chronic pain sensation and emotional components in rodents and humans.Therefore,taking functional gastrointestinal diseases irritable bowel syndrome(IBS)in chronic visceral pain as an example,we focused on these brain regions to highlight the current progress in the neural circuits of negative emotions induced by visceral pain in rodent models of irritable bowel syndrome.In this process,we also discussed important research directions related to this field in the future,providing new clues for revealing the mechanisms of chronic visceral pain and inducing negative emotions.