调经促孕十三针对高龄卵巢储备功能减退患者卵巢功能的影响

Effects of"Thirteen acupoints for regulating menstruation and promoting pregnancy"on ovarian function in elderly patients with DOR

目的观察调经促孕十三针对高龄卵巢储备功能减退(DOR)患者卵巢功能的影响。方法选取2021年1月至2023年1月于武汉康健妇婴医院就诊高龄DOR患者90例为研究对象,将符合纳入标准的患者按照随机数字表法分为针刺组和对照组,每组45例。针刺组经调经促孕针法针刺12周,对照组不予任何针刺治疗。观察并比较治疗前后两组患者性激素水平及卵巢基础窦卵泡数(bAFC)和改良Kupperman量表总评分。结果治疗前,两组患者bAFC、基础卵泡刺激素(bFSH)、基础黄体生成激素(bLH)、基础雌二醇(bE_(2))和抗缪勒管激素(AMH)水平比较,差异无统计学意义(P>0.05);治疗后,针刺组患者bFSH和bLH优于对照组,差异有统计学意义(P<0.05),两组患者卵泡刺激素/黄体生成素(FSH/LH)、bAFC差异无统计学意义(P>0.05)。针刺组患者bFSH、bLH、FSH/LH、bAFC均显著优于治疗前,差异有统计学意义(P<0.05,P<0.01);治疗前后,两组患者bE2均无统计学意义(P>0.05)。针刺组患者治疗后改良Kupperman量表总评分较治疗前降低,差异有统计学意义(P<0.05)。结论调经促孕十三针能提高高龄DOR患者的卵巢功能。

Objective To observe the effect of"thirteen acupoints for regulating menstruation and promoting pregnancy"on elderly patients with diminished ovarian reserve(DOR).Methods A total of 90 elderly patients with DOR who were treated in Wuhan Kangjian Maternal and Infants Hospital from January 2021 to January 2023 were selected as the research objects.The patients who met the inclusion criteria were divided into an acupuncture group and a control group according to the random number table method,with 45 cases in each group.The patients in the acupuncture group were treated with acupuncture for regulating menstruation and promoting pregnancy for 12 weeks,while the patients in the control group received no acupuncture treatment.The sex hormone levels,bilateral ovarian basal antral follicle count(bAFC)and modified Kupperman scale total score were observed and compared between the two groups before and after treatment.Results Before treatment,there were no significant differences in the bAFC,basic follicle-stimulating hormone(bFSH),basic luteinizing hormone(bLH),basic estradiol(bE_(2))or anti-Müllerian hormone(AMH)between the two groups(P>0.05).After treatment,the bFSH andthe bLH,in the acupuncture group were better than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in FSH/LH or bAFC between the two groups(P>0.05).The bFSH,bLH,FSH/LH and bAFC in the acupuncture group were significantly better than those before treatment,and the differences were statistically significant(P<0.05,P<0.01).There was no significant difference in bE2 between the two groups before or after treatment(P>0.05).After treatment,the total score of modified Kupperman scale in the acupuncture group was lower than that before treatment,and the difference was statistically significant(P<0.05).Conclusions"Thirteen acupoints for regulating menstruation and promoting pregnancy"can improve the ovarian function in elderly patients with DOR.