肿瘤相关巨噬细胞在弥漫大B细胞淋巴瘤免疫微环境中的研究进展

Advances in the study of tumor-associated macrophages in the immune microenvironment of diffuse large B-cell lymphoma

弥漫大B细胞淋巴瘤(DLBCL)是发病率最高的淋巴瘤亚型。肿瘤相关巨噬细胞(TAMs)是肿瘤微环境(TME)中的重要组成部分,具有促进DLBCL的生长增殖、逃脱机体免疫、降低生存期等一系列作用。鉴于TAMs对DLBCL具有重要的意义,本文就目前有关TAMs对DLBCL免疫微环境中的作用进行简要综述,对TAMs的形成、分类、逆转M2型为M1型以及相关因子的作用机制,预后影响等方面进行了简略总结,并对TAMs相关的分子靶向治疗及新药物等进行简要阐述。

Diffuse large B-cell lymphoma(DLBCL)is the most prevalent subtype of lymphoma.Tumor-associated macrophages(TAMs)have emerged as crucial components of the tumor microenvironment(TME),exerting a series of effects that promote the growth and proliferation of DLBCL,facilitating evasion from the host immune system,and reducing overall survival.Given the significance of TAMs in DLBCL,this article provides a brief review of the current study on the role of TAMs in the immune microenvironment of DLBCL,including briefly summarization of the formation and classification of TAMs,phenotypic conversion from M2 to M1 as well as the mechanisms of related factors,and prognostic implications.Furthermore,it briefly discusses the molecular targeted therapies and new drugs related to TAMs.